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Multi Step Selection in Ig H Chains is Initially Focused on CDR3 and Then on Other CDR Regions

Frontiers in Immunology

Sep 17, 2013

Gilad Libermanyoram louzoun

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Abstract

the choice of appropriate clones (clonal selection), and the internal evolution within clones, induced by somatic hyper-mutations, where high affinity mutants are selected for. When a final population of immunoglobulin sequences is observed, the genetic composition of this population is...read more

Mentioned in this Paper

Anatomical Maturation
Sampling - Surgical Action
Mutant
Mutation Abnormality
Imbalance
CEREBELLAR DEGENERATION-RELATED AUTOANTIGEN 3
Clone
Immunoglobulin Activity
CDR1 gene
CDR1 protein, human
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Multi Step Selection in Ig H Chains is Initially Focused on CDR3 and Then on Other CDR Regions

Frontiers in Immunology

Sep 17, 2013

Gilad Libermanyoram louzoun

PMID: 24062742

DOI: 10.3389/fimmu.2013.00274

Abstract

the choice of appropriate clones (clonal selection), and the internal evolution within clones, induced by somatic hyper-mutations, where high affinity mutants are selected for. When a final population of immunoglobulin sequences is observed, the genetic composition of this population is...read more

Mentioned in this Paper

Anatomical Maturation
Sampling - Surgical Action
Mutant
Mutation Abnormality
Imbalance

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