Multi-stimuli responsive Cu2S nanocrystals as trimodal imaging and synergistic chemo-photothermal therapy agents

Nanoscale
Aby Cheruvathoor PouloseD Sakthi Kumar

Abstract

A size and shape tuned, multifunctional metal chalcogenide, Cu2S-based nanotheranostic agent is developed for trimodal imaging and multimodal therapeutics against brain cancer cells. This theranostic agent was highly efficient in optical, photoacoustic and X-ray contrast imaging systems. The folate targeted NIR-responsive photothermal ablation in synergism with the chemotherapeutic action of doxorubicin proved to be a rapid precision guided cancer-killing module. The multi-stimuli, i.e., pH-, thermo- and photo-responsive drug release behavior of the nanoconjugates opens up a wider corridor for on-demand triggered drug administration. The simple synthesis protocol, combined with the multitudes of interesting features packed into a single nanoformulation, clearly demonstrates the competing role of this Cu2S nanosystem in future cancer treatment strategies.

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Citations

Sep 23, 2016·Chemical Reviews·Gaixia XuParas N Prasad
Oct 25, 2016·Scientific Reports·Aby Cheruvathoor PouloseD Sakthi Kumar
Apr 11, 2017·Chemical Reviews·Claudia CoughlanKevin M Ryan
Jun 2, 2017·Advanced Healthcare Materials·Vimalkumar BalasubramanianHélder A Santos
Jan 18, 2018·Antioxidants & Redox Signaling·Shamim Akhtar SufiRukkumani Rajagopalan
Apr 1, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Baofeng YunZhen Li
Nov 7, 2019·Frontiers in Bioengineering and Biotechnology·Zuhong LiLanjuan Li
May 7, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Tan LiTongsheng Chen
Nov 7, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Srivani VeeranarayananD Sakthi Kumar
Mar 5, 2021·International Journal of Nanomedicine·Ruixin JiaYe Bi
Jun 3, 2021·Pharmaceutics·Yuseon ShinKyungtaek Oh
Jul 4, 2021·International Journal of Pharmaceutics·Achalla Vaishnav Pavan KumarPrashant Kesharwani

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