Multi-stimuli responsive nanogel/hydrogel nanocomposites based on κ-carrageenan for prolonged release of levodopa as model drug.

International Journal of Biological Macromolecules
Ghasem Rezanejade BardajeeCédric Vancaeyzeele

Abstract

This study describes the development of a novel biocompatible nanogel/hydrogel nanocomposite system for long-term delivery of bioactive molecules. To this aim, the nanogels were synthesized via radical polymerization of poly(N-isopropylacrylamide). The nanogels were introduced during the formation of a hydrogel network to produce nanogel/hydrogel soft nanocomposites, while the biocompatible hydrogel was based on poly (acrylic acid) grafted onto κ-carrageenan polysaccharide with entrapped magnetic iron oxide nanoparticles as crosslinker. In these systems, by using stimuli-responsive functional polymers in both gels (nanogels and hydrogels), pH, thermal and magnetic-responsive properties can be brought to final soft nanocomposites. The obtained soft nanocomposite was characterized by Fourier transform infrared spectrum (FT-IR), thermogravimetric (TG) analysis, and scanning electron microscopy (SEM). This biopolymer based nanogel/hydrogel used as a prolonged releasing drug carrier for levodopa (L-DOPA) as a main drug for treating Parkinson's symptoms. The in vitro release of L-DOPA was investigated at different pHs. pH-dependent release of the active drug can be sustained for >11 days from this soft nanocomposite. The results demo...Continue Reading

Citations

Jul 19, 2020·Journal of Biomedical Materials Research. Part a·Bowen TanJinfeng Liao
Sep 16, 2020·International Journal of Molecular Sciences·Filippo PinelliFilippo Rossi
Feb 10, 2021·Nanomaterials·Magdalena Aflori
Mar 4, 2021·Neurochemistry International·Uma Maheswari Krishnan
Apr 3, 2021·International Journal of Biological Macromolecules·Lidiane Rodrigues AntunesDouglas Cardoso Dragunski
May 15, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·V MoralesR A García-Muñoz
Aug 28, 2021·International Journal of Biological Macromolecules·Azarmidokht Gholamipour-ShiraziTom Mills
Nov 13, 2021·ACS Applied Materials & Interfaces·Hao WangHan Zhang

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