Multi-unit floating alginate system: effect of additives on ciprofloxacin release

Drug Delivery
A Srinatha, J K Pandit

Abstract

In an attempt to fabricate floating beads of ciprofloxacin, drugloaded alginate beads were prepared by simultaneous external and internal gelation. The effect of blending of alginate with gellan, hydroxypropyl methylcellulose, starch, and chitosan on the bead properties were evaluated. Beads were spherical with incorporation efficiency in the range of 52.81 +/- 2.64 to 78.95 +/- 1.92%. Beads exhibited buoyancy over a period of 7-24 hr based on the formulation variables. In vitro release of ciprofloxacin from the alginate beads in simulated gastric fluid (SGF) (0.1 N HCl, pH 1.2), was influenced significantly (p < 0.001) by the properties and concentration of additives. Among the polymers incorporated into alginate beads. Hydroxy propyl methylcellulose (HPMC) provided an extended release over 7 hr. The drug release predominately followed Higuchi's square root model.

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Citations

Mar 12, 2009·AAPS PharmSciTech·Ramji Anil Kumar ArzaPrabhakar Reddy Veerareddy
Mar 27, 2012·Expert Opinion on Drug Delivery·Rakesh PahwaKanchan Kohli
Oct 1, 2015·Drug Development and Industrial Pharmacy·Yanhua LiuWenping Wang
Sep 28, 2018·Drug Development and Industrial Pharmacy·Sayed IsmailDina Adel Abdelmalek
Mar 1, 2012·Applied Biochemistry and Biotechnology·Germán A IslanGuillermo R Castro
Dec 15, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Thangavelu MuthukumarGilson Khang

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