Multi-variable models of large International Prostate Symptom Score worsening at the end of therapy in prostate cancer radiotherapy

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
Federica PaloriniClaudio Fiorino

Abstract

Prospectively assessing clinical/dosimetry factors affecting the acute worsening of urinary functionality after radiotherapy for prostate cancer. DUE01 population was considered, including patients treated with conventional or moderate hypo-fractionation (2.2-2.7 Gy/fr). Relevant clinical factors were collected, urinary symptoms were self-reported through the International Prostate Symptom Score (IPSS) before and at the end of radiotherapy; while absolute weekly dose-surface histograms (DSHw) were chosen as dosimetry descriptors. An IPSS increase of at least 10 and 15 points (ΔIPSS ⩾ 10 and ΔIPSS ⩾ 15) were chosen as endpoints. Patients with baseline IPSS>20 were excluded. Relevant factors were chosen through a bootstrap-based in silico methodology. Complete information was available for 380 patients: 77/380 (20%) and 28/380 (7%) with ΔIPSS ⩾ 10 and ΔIPSS ⩾ 15, respectively. Neoadjuvant hormone was protective (OR=0.49 and 0.69). DSHw at 8.5 Gy/week and 12 Gy/week were risk factors, with additional risk for patients who use cardiovascular drugs and anti-hypercholesterolemia drugs. In the hypo-fractionated subgroup (n=209) the role of cardiovascular drugs (OR=2.16) for ΔIPSS ⩾ 10 and anti-hypercholesterolemia drugs (OR=2.80) for ...Continue Reading

References

May 15, 1991·International Journal of Radiation Oncology, Biology, Physics·B EmamiM Wesson
Mar 30, 1995·International Journal of Radiation Oncology, Biology, Physics·L B MarksM S Anscher
Sep 22, 2009·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Claudio FiorinoGiuseppe Sanguineti
Mar 5, 2010·International Journal of Radiation Oncology, Biology, Physics·Akila N ViswanathanWilliam U Shipley
Sep 8, 2010·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Tara RosewallMichael Milosevic
Mar 10, 2012·International Journal of Radiation Oncology, Biology, Physics·Viviana CarilloClaudio Fiorino
Nov 28, 2012·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Viviana CarilloClaudio Fiorino
Jan 15, 2014·International Journal of Radiation Oncology, Biology, Physics·Pirus GhadjarAndrew Jackson
Mar 19, 2014·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Viviana CarilloClaudio Fiorino

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Citations

Jul 3, 2016·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Noorazrul YahyaJames W Denham
Sep 19, 2019·Physics and Imaging in Radiation Oncology·Catharine H ClarkLudvig P Muren
Dec 29, 2020·Frontiers in Psychology·Maria Francesca AlvisiUNKNOWN Prostate Cancer Multidisciplinary Clinic Working Group
Feb 5, 2019·International Journal of Radiation Oncology, Biology, Physics·Eugenia MylonaRenaud de Crevoisier
Apr 1, 2020·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Eugenia MylonaRenaud de Crevoisier

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