Multi-voxel pattern analysis of amygdala functional connectivity at rest predicts variability in posttraumatic stress severity.

Brain and Behavior
Jacklynn M FitzgeraldChristine L Larson

Abstract

Resting state functional magnetic resonance imaging (rsfMRI) studies demonstrate that individuals with posttraumatic stress disorder (PTSD) exhibit atypical functional connectivity (FC) between the amygdala, involved in the generation of emotion, and regions responsible for emotional appraisal (e.g., insula, orbitofrontal cortex [OFC]) and regulation (prefrontal cortex [PFC], anterior cingulate cortex). Consequently, atypical amygdala FC within an emotional processing and regulation network may be a defining feature of PTSD, although altered FC does not seem constrained to one brain region. Instead, altered amygdala FC involves a large, distributed brain network in those with PTSD. The present study used a machine-learning data-driven approach, multi-voxel pattern analysis (MVPA), to predict PTSD severity based on whole-brain patterns of amygdala FC. Trauma-exposed adults (N = 90) completed the PTSD Checklist-Civilian Version to assess symptoms and a 5-min rsfMRI. Whole-brain FC values to bilateral amygdala were extracted and used in a relevance vector regression analysis with a leave-one-out approach for cross-validation with permutation testing (1,000) to obtain significance values. Results demonstrated that amygdala FC predi...Continue Reading

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Citations

Sep 4, 2021·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Jacklynn M FitzgeraldChristine L Larson

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Methods Mentioned

BETA
cognitive behavioral therapy

Software Mentioned

PRoNTo
SPM12
MPVA
MVPA
RVR
CONN FC
SPM

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