Multi-wavelength photo-acoustic microscopy in the frequency domain for simultaneous excitation and detection of dyes

Biomedical Optics Express
Olivier HugonEric Lacot

Abstract

An optical-resolution photoacoustic microscope with modulated CW laser diodes allowing multi-channel imaging is presented that can be used for both imaging biological tissues and for targeted photo-dynamic therapy (PDT) varying the optical power and exposure time. The effects of this therapy are immediately monitored in order to optimize the time of irradiation. After the description of the experimental setup, in vitro and in vivo applications are presented on a synthetic sample and on the mouse ear using hemoglobin as endogenous and methylene blue as exogenous dye for imaging and PDT, respectively.

References

Jan 26, 2011·Optics Letters·Lidai WangLihong V Wang
Mar 29, 2013·Proceedings of the National Academy of Sciences of the United States of America·Lidai WangLihong V Wang
Mar 25, 2014·American Journal of Physics·Peter LeboulluecBaohong Yuan
Mar 11, 2016·Journal of Neuro-oncology·Lauriane HamardDidier Wion
Jul 23, 2016·Biomedical Optics Express·Gregor LangerThomas Berer
Nov 29, 2016·Current Pharmaceutical Design·Carsten Lange, Patrick J Bednarski
Sep 26, 2017·Future Oncology·Clément DupontMaximilien Vermandel
Apr 13, 2018·International Journal of Molecular Sciences·Barbara KoflerJozsef Dudas

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Citations

Mar 25, 2020·Biomedical Optics Express·Boudewijn van der SandenEric Lacot

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