Multicenter analysis of fecal microbiota profiles in Japanese patients with Crohn's disease.

Journal of Gastroenterology
Akira AndohTakayuki Matsumoto

Abstract

We analyzed the fecal microbiota profiles of patients with Crohn's disease (CD) at 4 inflammatory bowel disease (IBD) centers located in different districts in Japan. Terminal restriction fragment length polymorphism (T-RFLP) analysis was performed in 161 fecal samples from CD patients and 121 samples from healthy individuals. The bacterial diversity was evaluated by the Shannon diversity index (SDI). There were no regional differences in the fecal microbiota profiles of the healthy individuals in Japan. A setting of similarity generated three major clusters of T-RFs: one included almost all the healthy individuals (118/121), and the other two clusters were mainly formed by CD patients at different stages of disease activity. The changes in simulated bacterial composition indicated that the class Clostridia, including the genus Faecalibacterium, was significantly decreased in CD patients with active disease and those in remission as compared with findings in the healthy individuals. In contrast, the genus Bacteroides was significantly increased in CD patients during the active phase as compared with findings in the healthy individuals. The genus Bifidobacterium was significantly decreased during the active phase of CD and incre...Continue Reading

References

Jan 10, 2002·Gastroenterology·Alexander SwidsinskiHerbert Lochs
Aug 9, 2002·The New England Journal of Medicine·Daniel K Podolsky
Jan 2, 2003·International Journal of Systematic and Evolutionary Microbiology·Sylvia H DuncanHarry J Flint
Apr 9, 2005·Alimentary Pharmacology & Therapeutics·T NomuraN Sato
Feb 28, 2006·Journal of Gastroenterology·Toshifumi Hibi, Haruhiko Ogata
Apr 6, 2006·Journal of Medical Microbiology·Katja LuckeMarkus Schuppler
Jul 5, 2006·Nature Clinical Practice. Gastroenterology & Hepatology·R Balfour Sartor
Sep 12, 2006·Alimentary Pharmacology & Therapeutics·P SeksikP Marteau
Nov 30, 2006·Current Opinion in Gastroenterology·Nicolas Barnich, Arlette Darfeuille-Michaud
Dec 22, 2006·Nature·Ruth E LeyJeffrey I Gordon
Feb 27, 2007·Journal of Gastroenterology·Bruce E Sands
Aug 19, 2007·Proceedings of the National Academy of Sciences of the United States of America·Daniel N FrankNorman R Pace
Aug 24, 2007·The Lancet Infectious Diseases·Martin FellerMatthias Egger
Sep 11, 2007·Advanced Drug Delivery Reviews·Stefan Wirtz, Markus F Neurath
Oct 6, 2007·DNA Research : an International Journal for Rapid Publication of Reports on Genes and Genomes·Ken KurokawaMasahira Hattori
Nov 28, 2007·Annual Review of Pathology·Jonathan Braun, Bo Wei
Feb 5, 2008·Gastroenterology·R Balfour Sartor
Feb 26, 2008·Journal of Gastroenterology·Atsushi Mizoguchi, Emiko Mizoguchi
Oct 1, 2008·Scandinavian Journal of Gastroenterology·Jun NishikawaToshiro Sugiyama
Oct 22, 2008·Proceedings of the National Academy of Sciences of the United States of America·Harry SokolPhilippe Langella
Feb 25, 2009·Inflammatory Bowel Diseases·H SokolJ Doré
Jun 13, 2009·Current Pharmaceutical Design·Akira AndohYoshihide Fujiyama
Feb 1, 2003·FEMS Microbiology Ecology·Tom C J HillBruce F Moffett
Dec 5, 2009·Journal of Gastroenterology·Lloyd Mayer
Aug 4, 2010·Proceedings of the National Academy of Sciences of the United States of America·Carlotta De FilippoPaolo Lionetti
Aug 19, 2011·Alimentary Pharmacology & Therapeutics·T AomatsuA Andoh
Sep 22, 2011·Inflammatory Bowel Diseases·Nabeetha A Nagalingam, Susan V Lynch
Sep 22, 2011·Inflammatory Bowel Diseases·Amrita KabiChristine McDonald
Jan 5, 2012·Journal of Gastroenterology·Matthew J HamiltonRichard S Blumberg

❮ Previous
Next ❯

Citations

Jun 11, 2015·Journal of Clinical Biochemistry and Nutrition·Azusa TakaokaYoshiko Miyazaki
Sep 2, 2015·ILAR Journal·Christoph BeckerStefan Wirtz
Dec 19, 2013·Gastroenterology Research and Practice·Lill Therese ThorkildsenKnut Rudi
Oct 13, 2012·Gut Microbes·Gunnar Loh, Michael Blaut
Jan 7, 2015·Pharmacology & Therapeutics·Giovanni CammarotaDiego Currò
Sep 30, 2016·Microorganisms·Ishfaq AhmedShahid Umar
Oct 25, 2016·Critical Reviews in Biochemistry and Molecular Biology·Magali de BruynGhislain Opdenakker
Aug 27, 2016·Nature Microbiology·Shinsaku OkaiReiko Shinkura
Oct 1, 2016·Scandinavian Journal of Gastroenterology·Michelle ProsbergLise L Gluud
Jan 2, 2013·Diagnostic Microbiology and Infectious Disease·Sumei ShaKaichun Wu
Oct 25, 2016·International Journal of Molecular Sciences·Lynnette R Ferguson, Matthew P G Barnett
Oct 14, 2016·Scientific Reports·Danyta I TedjoDaisy M A E Jonkers
Oct 11, 2015·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Daniela Elena Serban
Sep 30, 2016·Microorganisms·Yao-Jong Yang, Bor-Shyang Sheu
Nov 19, 2013·Inflammatory Bowel Diseases·Lani PrideauxMichael A Kamm
Sep 24, 2014·Inflammatory Bowel Diseases·Jennifer LiAlain Stintzi
Mar 2, 2018·Human Vaccines & Immunotherapeutics·Audrey Humphries, Adil Daud
Nov 4, 2017·Expert Opinion on Therapeutic Targets·Magali de Bruyn, Séverine Vermeire
Apr 28, 2018·Inflammatory Bowel Diseases·Williams TurpinKenneth Croitoru Mdcm
Mar 24, 2017·Journal of Clinical Microbiology·A EckA E Budding
Jan 22, 2019·Nature Medicine·Bahtiyar YilmazAndrew J Macpherson
May 9, 2019·Journal of Crohn's & Colitis·Marjolein A Y KlaassenRinse K Weersma
Dec 12, 2012·Journal of Gastroenterology and Hepatology·Takehide FujimotoAkira Andoh
Apr 23, 2013·Clinical and Experimental Immunology·H ImaedaA Andoh
Sep 28, 2013·Current Opinion in Clinical Nutrition and Metabolic Care·Alexander Neef, Yolanda Sanz
Jan 24, 2014·Clinical and Experimental Immunology·N-E SerriariE Treiner
Mar 8, 2020·Journal of Clinical Medicine·Kinga Kowalska-DuplagaKrzysztof Fyderek
Jan 4, 2020·Journal of Pediatric Gastroenterology and Nutrition·Sara SilaSanja Kolaček
May 17, 2019·Terapevticheskiĭ arkhiv·N A DanilovaR A Abdulkhakov

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.