Multicenter European external validation of a prostate health index-based nomogram for predicting prostate cancer at extended biopsy.

European Urology
Giovanni LughezzaniGiorgio Guazzoni

Abstract

External validation of a prediction tool is mandatory to assess the tool's accuracy and generalizability within different patient cohorts. To externally validate a previously developed Prostate Health Index (PHI)-based nomogram for predicting the presence of prostate cancer (PCa) at biopsy. The study population consisted of 883 patients who were scheduled for a prostate biopsy at one of five European tertiary care centers. Total prostate-specific antigen (tPSA), free prostate-specific antigen (fPSA), and [-2]pro-prostate-specific antigen (p2PSA) levels were determined. The fPSA-to-tPSA ratio (%fPSA), p2PSA, and PHI ([p2PSA / fPSA] × √tPSA) were calculated. Extended initial and repeat prostate biopsy. Logistic regression models were fitted to test the predictors of PCa and to determine their predictive accuracy. A calibration plot was used to evaluate the extent of overestimation or underestimation between nomogram predictions and observed PCa rate. Decision curve analysis (DCA) provided an estimate of the net benefit obtained by using the PHI-based nomogram. Of 833 patients, 365 (41.3%) were diagnosed with PCa at extended prostate biopsy. In accuracy analyses, PHI was the most informative predictor of PCa (0.68), outperforming ...Continue Reading

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Citations

Aug 20, 2014·International Journal of Clinical Oncology·Kazuto ItoBernard Cook
Nov 29, 2015·The Urologic Clinics of North America·Abbey LeporStacy Loeb
Sep 12, 2015·Future Oncology·Carsten StephanBernhard Ralla
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Oct 16, 2016·BJU International·Stacy LoebWilliam J Catalona
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Nov 14, 2019·Abdominal Radiology·Amihay NevoPaul Andrews
Jun 5, 2016·Current Opinion in Urology·Stacy LoebAndrew Vickers
Jan 13, 2015·Clinical Chemistry and Laboratory Medicine : CCLM·Xavier Filella, Laura Foj
Nov 7, 2017·The Urologic Clinics of North America·Stacy Loeb, Hasan Dani

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