Multicenter Evaluation of a 0-Hour/1-Hour Algorithm in the Diagnosis of Myocardial Infarction With High-Sensitivity Cardiac Troponin T

Annals of Emergency Medicine
Christian MuellerTRAPID-AMI Investigators

Abstract

We aim to prospectively validate the diagnostic accuracy of the recently developed 0-h/1-h algorithm, using high-sensitivity cardiac troponin T (hs-cTnT) for the early rule-out and rule-in of acute myocardial infarction. We enrolled patients presenting with suspected acute myocardial infarction and recent (<6 hours) onset of symptoms to the emergency department in a global multicenter diagnostic study. Hs-cTnT (Roche Diagnostics) and sensitive cardiac troponin I (Siemens Healthcare) were measured at presentation and after 1 hour, 2 hours, and 4 to 14 hours in a central laboratory. Patient triage according to the predefined hs-cTnT 0-hour/1-hour algorithm (hs-cTnT below 12 ng/L and Δ1 hour below 3 ng/L to rule out; hs-cTnT at least 52 ng/L or Δ1 hour at least 5 ng/L to rule in; remaining patients to the "observational zone") was compared against a centrally adjudicated final diagnosis by 2 independent cardiologists (reference standard). The final diagnosis was based on all available information, including coronary angiography and echocardiography results, follow-up data, and serial measurements of sensitive cardiac troponin I, whereas adjudicators remained blinded to hs-cTnT. Among 1,282 patients enrolled, acute myocardial infar...Continue Reading

References

Aug 16, 2006·Annals of Internal Medicine·Andrew S LeveyUNKNOWN Chronic Kidney Disease Epidemiology Collaboration
Aug 28, 2009·The New England Journal of Medicine·Tobias ReichlinChristian Mueller
Aug 28, 2009·The New England Journal of Medicine·Till KellerStefan Blankenberg
Dec 5, 2009·Clinical Chemistry·Evangelos GiannitsisHugo A Katus
Sep 17, 2011·Journal of the American College of Cardiology·Richard BodyKevin Mackway-Jones
Dec 29, 2011·JAMA : the Journal of the American Medical Association·Till KellerStefan Blankenberg
Mar 28, 2012·The New England Journal of Medicine·Harold I LittJudd E Hollander
Jun 23, 2012·European Heart Journal·Kristian ThygesenUNKNOWN Study Group on Biomarkers in Cardiology of ESC Working Group on Acute Cardiac Care
Jul 27, 2012·The New England Journal of Medicine·Udo HoffmannUNKNOWN ROMICAT-II Investigators
Aug 16, 2012·Archives of Internal Medicine·Tobias ReichlinChristian Mueller
Sep 11, 2012·Journal of the American College of Cardiology·Kristian ThygesenDaniel R Wagner
Jun 19, 2013·Circulation·Eugene Braunwald, David A Morrow
Jul 24, 2013·International Journal of Cardiology·Maria Rubini GiménezChristian Mueller
Dec 21, 2013·European Heart Journal·Christian Mueller
Dec 1, 2012·Global Heart·Kristian ThygesenHarvey D White
Feb 25, 2015·International Journal of Cardiology·Bernadette MellerChristian Mueller
Apr 4, 2015·The American Journal of Medicine·Maria Rubini GimenezChristian Mueller
Apr 15, 2015·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Tobias ReichlinChristian Mueller
Apr 29, 2015·International Journal of Cardiology·Karin WildiChristian Mueller

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Citations

Feb 16, 2016·International Journal of Cardiology·Matthias Mueller-HennessenUNKNOWN TRAPID-AMI Investigators
May 25, 2016·Annals of Emergency Medicine·Christian MuellerBertil Lindahl
May 29, 2016·European Heart Journal·Evangelos Giannitsis, Hugo A Katus
Feb 15, 2016·Annals of Emergency Medicine·Allan S Jaffe
Oct 26, 2016·La Presse médicale·Sandrine Charpentier, Camille Chenevier-Gobeaux
Aug 2, 2016·Heart, Lung & Circulation·Derek P ChewUNKNOWN NHFA/CSANZ ACS Guideline 2016 Executive Working Group:
Sep 2, 2016·European Heart Journal·James L Januzzi
Jun 23, 2016·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Jason P Stopyra, Simon A Mahler
Oct 4, 2016·Annales de cardiologie et d'angéiologie·O NalletX Marcaggi
Dec 23, 2016·European Heart Journal·Filippo CreaUNKNOWN 2015 ESC NSTE-ACS Guidelines Task Force
Mar 26, 2016·European Heart Journal. Acute Cardiovascular Care·Fabio StalloneChristian Mueller
Apr 7, 2017·Nature Reviews. Cardiology·Dirk WestermannStefan Blankenberg
May 2, 2017·Critical Reviews in Clinical Laboratory Sciences·Marek KozinskiGrazyna Sypniewska
May 24, 2017·European Heart Journal. Acute Cardiovascular Care·Patricia Van Den Berg, Richard Body
May 14, 2017·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Arash MokhtariUlf Ekelund
Jul 7, 2017·European Journal of Clinical Investigation·Christiana SchernthanerDaniel Kretzschmar
Nov 3, 2017·Medicine·Christiana SchernthanerDaniel Kretzschmar
Dec 12, 2017·Critical Reviews in Clinical Laboratory Sciences·Aitor Alquézar-ArbéJorge Ordoñez-Llanos
May 29, 2018·Journal of Internal Medicine·M J Holzmann
Jan 31, 2018·Circulation·Christopher deFilippi, Stephen Seliger
Nov 5, 2017·Circulation·Raphael TwerenboldChristian Mueller
Feb 9, 2017·Circulation. Cardiovascular Quality and Outcomes·James McCordUNKNOWN TRAPID-AMI Investigators
Oct 18, 2018·Acta Cardiologica·Serkan ÜnlüAdnan Abacı
Sep 29, 2018·Annals of Medicine·Bashir AlaourThomas E Kaier
Feb 13, 2019·Critical Pathways in Cardiology·Christopher W BaughJohn T Nagurney
Feb 13, 2019·Critical Pathways in Cardiology·James McCordUNKNOWN TRAPID-AMI Investigators
Feb 13, 2019·Critical Pathways in Cardiology·Asad ShabbirJon Swinburn
Apr 5, 2017·Clinical Chemistry and Laboratory Medicine : CCLM·Eloisa Lopez-CalleThomas Keller
Jan 24, 2018·Emergency Medicine Journal : EMJ·Edward Carlton, Richard Body
Oct 5, 2019·Cardiology in Review·Whitney Potomac, Deborah B Diercks

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