PMID: 9554179Apr 29, 1998Paper

Multicenter evaluation of the in vitro activity of six broad-spectrum beta-lactam antimicrobial agents in Puerto Rico. The Puerto Rico Antimicrobial Resistance Study Group

Diagnostic Microbiology and Infectious Disease
G V DoernC Ramirez-Rhonda

Abstract

The minimum inhibitory concentrations of 6 broad-spectrum beta-lactam antimicrobial agents were determined by use of the Etest versus a total of 569 bacteria in 7 Puerto Rican hospital laboratories. These included 342 recent clinical isolates of Enterobacteriaceae, 63 Pseudomonas aeruginosa, 54 Acinetobacter species, and 110 oxacillin-susceptible staphylococci. Extended spectrum beta-lactamase production was noted among 11% of Klebsiella pneumoniae isolates. Hyperproduction of Amp C cephalosporinase was observed with > 20% of isolates of Enterobacter spp., Serratia spp., and Citrobacter freundii. The overall rank order of activity of the six beta-lactams examined in this study versus all clinical isolates was imipenem (95.8% susceptible) > cefepime (91.1%) > piperacillin/ tazobactam (82.3%) > cefotaxime (77.6%) > piperacillin (72.5%) > ceftazidime (67.0%).

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Citations

Feb 11, 2000·Diagnostic Microbiology and Infectious Disease·R N Jones
Aug 13, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Hilmar WisplinghoffMichael B Edmond
Oct 31, 2008·Diabetic Medicine : a Journal of the British Diabetic Association·S EspositoE Sarli

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