Multicenter observational cohort study of post-operative treatment for completely resected non-small-cell lung cancer of pathological Stage I (T1 >2 cm and T2 in TNM classification version 6)

Japanese Journal of Clinical Oncology
Tomoyuki HishidaHideo Kunitoh

Abstract

Post-operative adjuvant chemotherapy has been considered an effective strategy to reduce cancer recurrence and improve survival for resected non-small-cell lung cancer. The Japan Clinical Oncology Group has completed patient accrual for a randomized Phase III study (JCOG0707), which compares the survival benefit of UFT and S-1 for completely resected pathological Stage I (T1 >2 cm and T2 in TNM classification version 6) non-small-cell lung cancer. However, there is a growing concern that those who participated in clinical trials are highly selected patients and do not represent the 'real-world' population. This multicenter observational cohort study aims to analyze the backgrounds, pattern of care and outcomes of the patients who were excluded from the JCOG0707 study during the accrual period. The results of this cohort study will be useful for external validity of the results of clinical trial such as JCOG0707.

References

Apr 23, 2004·The New England Journal of Medicine·Harubumi KatoUNKNOWN Japan Lung Cancer Research Group on Postsurgical Adjuvant Chemotherapy
Apr 23, 2004·The New England Journal of Medicine·Robert B Diasio
Jul 30, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Chikuma HamadaHiromi Wada
May 29, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jean-Pierre PignonUNKNOWN LACE Collaborative Group
Nov 4, 2008·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Tallal YounisNathalie Saint-Jacques
Oct 31, 2009·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Chikuma HamadaHiromi Wada
May 26, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Noriyoshi SawabataUNKNOWN Japanese Joint Committee for Lung Cancer Registration

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