Multicenter phase 1/2 application of adenovirus-specific T cells in high-risk pediatric patients after allogeneic stem cell transplantation

Cytotherapy
Winnie IpWaseem Qasim

Abstract

Adenovirus (ADV) reactivation can cause significant morbidity and mortality in children after allogeneic stem cell transplantation. Antiviral drugs can control viremia, but viral clearance requires recovery of cell-mediated immunity. This study was an open-label phase 1/2 study to investigate the feasibility of generating donor-derived ADV-specific T cells (Cytovir ADV, Cell Medica) and to assess the safety of pre-emptive administration of ADV-specific T cells in high-risk pediatric patients after allogeneic hematopoietic stem cell transplantation (HSCT) to treat adenoviremia. Primary safety endpoints included graft-versus-host disease (GvHD), and secondary endpoints determined antiviral responses and use of antiviral drugs. Between January 2013 and May 2016, 92 donors were enrolled for the production of ADV T cells at three centers in the United Kingdom (UK), and 83 products were generated from 72 mobilized peripheral blood harvests and 20 steady-state whole blood donations. Eight children received Cytovir ADV T cells after standard therapy and all resolved ADV viremia between 15 and 127 days later. ADV-specific T cells were detectable using enzyme-linked immunospot assay (ELISpot) in the peripheral blood of all patients analy...Continue Reading

Citations

Mar 13, 2019·Clinical Transplantation·Diana F FlorescuUNKNOWN AST Infectious Diseases Community of Practice
Oct 24, 2019·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Rebecca E Schultze-FloreyBritta Maecker-Kolhoff
May 23, 2020·Expert Review of Clinical Immunology·Su Han Lum, Mary A Slatter
Mar 30, 2020·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Thurid Ahlenstiel-Grunow, Lars Pape
Aug 21, 2018·Current Opinion in Oncology·Juan MontoroManuel Guerreiro
Nov 13, 2020·Frontiers in Immunology·Sabrina BassoPatrizia Comoli
Feb 9, 2021·Frontiers in Immunology·Claudio AnnaloroFrancesco Onida

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