Multicenter phase II randomized study evaluating dose-response of antiperistaltic effect of L-menthol sprayed onto the gastric mucosa for upper gastrointestinal endoscopy

Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society
Naoki HikiH Suzuki

Abstract

Peppermint oil solution was found to be effective for reducing gastric spasm during upper gastrointestinal endoscopy. The aim of the present study was to assess whether the gastric peristalsis-suppressing effect is dose-dependently induced by L-menthol, the major constituent of peppermint oil, and to determine the recommended dose of an L-menthol preparation. In this phase II, multicenter, double-blind, dose-response study, 131 eligible patients were randomly assigned to receive 20 mL of 0.4% L-menthol (n = 32), 0.8% L-menthol (n = 35), 1.6% L-menthol (n = 30), or placebo (n = 34). The primary efficacy measure was the proportion of subjects with no peristalsis in two time periods, 75 to 105 s after treatment and immediately before the completion of endoscopy. The peristalsis-suppressing effect of L-menthol increased dose dependently (5.6%, 32.0%, 47.4% and 52.9% in the 0%, 0.4%, 0.8% and 1.6% groups, respectively: P < 0.001, one-tailed Cochran-Armitage trend test). As compared with the placebo group, the proportion of subjects with no peristalsis after administration was significantly higher in the 0.8% group (P = 0.015) and 1.6% group (P = 0.009). Adverse events in the L-menthol dose groups occurred with similar frequencies in...Continue Reading

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Sep 5, 2013·Tobacco Induced Diseases·Atsuko NoriyasuTomonori Kawano
Dec 20, 2012·Case Reports in Medicine·Motaz BaibarsM Chadi Alraies
Apr 8, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Susanna SteaDalila De Pasquale
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May 1, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Simona Codruta HeghesLorena Filip
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Jun 15, 2021·JGH Open : an Open Access Journal of Gastroenterology and Hepatology·Akiyoshi IshiyamaJunko Fujisaki
Feb 26, 2019·Journal of Agricultural and Food Chemistry·Barbara PawłowskaRobert Biczak

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