Abstract
Amrubicin is a novel 9-aminoanthracycline. This multicenter phase II study was conducted to evaluate the efficacy and safety of amrubicin in patients with non-small-cell lung cancer (NSCLC). Sixty-one previously untreated patients with stage III or IV NSCLC were entered this study. The patients were required to have cytologically or histologically proven measurable NSCLC, an Eastern Cooperative Oncology Group (ECOG) performance status of 0-2, and adequate organ function. Amrubicin was administered by daily intravenous injection at 45 mg/m2/day for 3 consecutive days every 3 weeks. At least 3 cycles of treatment were administered to each patient. All 61 patients registered in this trial were eligible and assessable for efficacy and toxicity. Of them, 17 patients achieved objective responses, consisting of one complete response and 16 partial responses, and the overall response rate was 27.9% (95% confidence interval [CI], 17.1% to 40.8%). The median survival time was 9.8 months (95% CI, 7.7 months to 14.9 months). The major toxicity was myelosuppression. The incidences of grade 3 or 4 toxicity were 72.1% for neutropenia, 52.5% for leukopenia, 23.0% for anemia, and 14.8% for thrombocytopenia. As noticeable toxic events, grade 3 h...Continue Reading
References
Feb 1, 1992·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R FeldM Lassus
Mar 1, 1992·British Journal of Cancer·E F SmitP E Postmus
Jan 1, 1992·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E F SmitP E Postmus
Jan 1, 1991·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A MartoniF Pannuti
Jan 1, 1989·Japanese Journal of Cancer Research : Gann·S MorisadaM Fukui
Jan 1, 1989·Japanese Journal of Cancer Research : Gann·S MorisadaM Fukui
Feb 1, 1987·European Journal of Cancer & Clinical Oncology·K Aabo
Sep 1, 1974·Cancer·E P CortesJ F Holland
Apr 1, 1984·European Journal of Cancer & Clinical Oncology·R A JossM Rozencweig
Oct 7, 1995·BMJ : British Medical Journal
Jul 3, 1993·Lancet·P J SouquetE Rapp
Oct 1, 1993·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R GrilliJ A Julian
Jan 1, 1997·Investigational New Drugs·T SuzukiH Kanda
Dec 16, 1998·Investigational New Drugs·T NodaT Suzuki
Dec 16, 1998·Japanese Journal of Cancer Research : Gann·T NoguchiY Yanagi
Dec 16, 1998·Japanese Journal of Cancer Research : Gann·T YamaokaY Yanagi
Jan 23, 1999·Japanese Journal of Cancer Research : Gann·M HanadaT Yamaoka
Jul 14, 2005·Investigational New Drugs·Takahiko SugiuraMasahiro Fukuoka
Citations
Mar 15, 2012·Cancer Chemotherapy and Pharmacology·Maiko AsakumaNoriyuki Masuda
Jan 19, 2013·Cancer Chemotherapy and Pharmacology·Shuji MurakamiKouzo Yamada
May 9, 2008·International Journal of Clinical Oncology·Manabu KatouYoshiki Sugimura
May 14, 2010·International Journal of Clinical Oncology·Satoshi IgawaNoriyuki Masuda
Mar 14, 2007·Investigational New Drugs·Koji TakedaHarumichi Ikegami
Jul 14, 2007·Investigational New Drugs·Takayasu KurataMasahiro Fukuoka
Jun 4, 2011·Japanese Journal of Clinical Oncology·Hiroshi YoshidaTomohide Tamura
Oct 20, 2012·Japanese Journal of Clinical Oncology·Reiko Ando MakiharaHiroshi Yamamoto
Feb 28, 2013·The Oncologist·Toshiyuki HaradaUNKNOWN Hokkaido Lung Cancer Clinical Study Group
Oct 16, 2009·Expert Review of Anticancer Therapy·Michaela J Higgins, David S Ettinger
May 12, 2007·Expert Review of Anticancer Therapy·Roberta FerraldeschiPaul Lorigan
Feb 26, 2009·Expert Opinion on Drug Metabolism & Toxicology·Takayasu Kurata
Aug 5, 2010·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Kiyotaka YohYutaka Nishiwaki
Nov 4, 2009·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Hiroyasu KanedaUNKNOWN West Japan Thoracic Oncology Group
Oct 27, 2009·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Kyoichi KairaMasatomo Mori
Mar 8, 2016·Asia-Pacific Journal of Clinical Oncology·Yoshinori MakinoYoshikazu Hayashi
Feb 28, 2007·Trends in Molecular Medicine·Christine L Hann, Charles M Rudin
Jan 12, 2007·Cancer Science·Mitsuhara HanadaTakashi Yamaoka
Jul 28, 2009·Biomedical Chromatography : BMC·Reiko AndoHiroshi Yamamoto
Jul 28, 2015·American Journal of Clinical Oncology·Sakiko OtaniNoriyuki Masuda
May 11, 2016·Japanese Journal of Clinical Oncology·Yukiko MiuraAkihiko Gemma
Jan 9, 2013·Chemotherapy·Hiroyuki WatanabeRyozo Oishi
Dec 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sayaka OnodaUNKNOWN Thoracic Oncology Research Group Study 0301
Feb 14, 2007·The Oncologist·Luca Toschi, Federico Cappuzzo
Jan 9, 2014·International Journal of Oncology·Shizuka ItoEiji Shimizu
Nov 8, 2020·Investigational New Drugs·Sakiko OtaniNoriyuki Masuda
Apr 21, 2017·Annals of Oncology : Official Journal of the European Society for Medical Oncology·H YoshiokaK Nakagawa