PMID: 11316122Apr 24, 2001Paper

Multicenter prospective nonrandomized study of long-term antiarrhythmic drug therapy in patients with tachyarrhythmias: Japanese Antiarrhythmics Long-Term Study-2 (JALT-2 Study)

Japanese Circulation Journal
T KatohH Hayakawa

Abstract

Based on the results of the Cardiac Arrhythmia Suppression Trial (CAST), strategies for the treatment of tachyarrhythmias have changed rapidly. The Japanese Antiarrhythmics Long-Term (JALT) study was planned to investigate the present methods for choosing antiarrhythmic drugs, and the effects on long-term prognosis in patients with tachyarrhythmias in Japan. Following a 6-month preliminary study (JALT-1), there was a multicenter nonrandomized prospective study (JALT-2), with a 2-year follow-up, of patients with paroxysmal atrial fibrillation (PAF), sustained ventricular tachycardia (SVT) and nonsustained VT (NSVT). Four hundred fifty-five patients were registered, and 361 of them (79%) were analyzed. Cerebral infarction occurred in 10 of 193 patients (5.2%) with PAF. Transition to chronic AF was observed in 21 patients (10.9%), but in none of the patients receiving Ca antagonist therapy. Twenty-five patients died: 5 deaths were arrhythmic, 10 were because of pump failure, and 9 were noncardiac. The most significant difference in drug selection between JALT-1 and JALT-2 was the increase in the use of slow kinetic Na channel blockers for PAF and the decrease in the use of the same agents for VT in the JALT-2 study. A marked chang...Continue Reading

References

Jul 23, 1992·The New England Journal of Medicine·UNKNOWN Cardiac Arrhythmia Suppression Trial II Investigators
Dec 31, 1997·The New England Journal of Medicine·UNKNOWN Antiarrhythmics versus Implantable Defibrillators (AVID) Investigators
Oct 10, 1998·Japanese Circulation Journal

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Citations

Nov 10, 2009·Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine·Akira Yamashina
Apr 17, 2002·Circulation Journal : Official Journal of the Japanese Circulation Society·Takeshi AibaShiro Kamakura
Aug 27, 2003·Circulation Journal : Official Journal of the Japanese Circulation Society·Takeshi YamashitaUNKNOWN J-RHYTHM Investigators
Jun 1, 2004·Circulation Journal : Official Journal of the Japanese Circulation Society·Takeshi KatoLong-Tai Fu
Feb 27, 2007·Circulation Journal : Official Journal of the Japanese Circulation Society·Taira FukudaTadanori Aizawa
Jan 25, 2006·Circulation·T Jared Bunch, Michael J Ackerman

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