Abstract
This study compared the efficacy and safety of adjunctive brimonidine tartrate 0.1% ophthalmic solution (brimonidine) and timolol maleate 0.5% ophthalmic solution (timolol) in prostaglandin analogue (PGA)-treated normal-tension glaucoma (NTG), assessing the non-inferiority of brimonidine in terms of intraocular pressure (IOP) reduction. In this multicenter, randomized, investigator-masked, parallel-group, clinical study, adjunctive brimonidine or timolol was administered twice daily for 12 weeks in eyes with NTG that had been treated with PGA for at least 90 days and required additional treatment despite an IOP of 16 mmHg or less. IOP was measured on at least three visits before add-on therapy (mean baseline IOP), and at weeks 4, 8, and 12 after adjunctive administration. Systolic/diastolic blood pressure, pulse rate, and adverse events (AEs) were recorded at each visit. A total of 152 individuals were enrolled and 128 (84.2%) were eligible for efficacy analyses. IOP in both groups at each visit decreased significantly from baseline (P < 0.001). However, the difference in the change from baseline IOP at week 12 between the brimonidine (-1.05 ± 1.81 mmHg) and timolol (-1.41 ± 1.40 mmHg) groups was 0.36 mmHg (95% confidence inter...Continue Reading
References
Nov 15, 1986·American Journal of Ophthalmology·W L NelsonJ N Kuritsky
Jun 1, 1984·American Journal of Ophthalmology·J Caprioli, G L Spaeth
Oct 1, 1995·Archives of Ophthalmology·A Lee
Oct 21, 1998·American Journal of Ophthalmology
Jul 23, 1999·Survey of Ophthalmology·S S Hayreh
Oct 12, 2000·American Journal of Ophthalmology
Feb 13, 2001·Ophthalmology·D R AndersonUNKNOWN Collaborative Normal-Tension Glaucoma Study Group
Apr 6, 2005·Ophthalmology·Anastasios G P KonstasWilliam C Stewart
Aug 23, 2005·Ophthalmology·Tetsuya YamamotoUNKNOWN Tajimi Study Group, Japan Glaucoma Society
Jul 14, 2007·Ophthalmology·M Cristina LeskeUNKNOWN EMGT Group
Apr 15, 2009·Archives of Ophthalmology·Meredith SaylorMichael S Lee
May 20, 2009·Ophthalmology·Jin-Wei ChengRui-Li Wei
Jun 24, 2009·Ophthalmic Research·Jin-Wei ChengRui-Li Wei
Feb 13, 2010·Japanese Journal of Ophthalmology·Sei YamazakiKeiji Yoshikawa
Apr 20, 2010·Japanese Journal of Ophthalmology·Akira AoyamaTetsuya Yamamoto
Jul 29, 2010·Ophthalmology·John H K LiuRobert N Weinreb
Jan 25, 2011·American Journal of Ophthalmology·Theodore KrupinUNKNOWN Low-Pressure Glaucoma Study Group
Oct 12, 2012·Clinical Ophthalmology·Toyoaki TsumuraRyuji Takeda
Feb 15, 2013·Acta Ophthalmologica·Martha KimSeok Hwan Kim
Apr 9, 2013·Advances in Therapy·Sangmoon LeeDong Myung Kim
Jun 28, 2014·Clinical Ophthalmology·Kenji InoueGoji Tomita
Aug 19, 2014·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Shinya KomoriTetsuya Yamamoto
Sep 13, 2014·Clinical Ophthalmology·Toyoaki TsumuraRyuji Takeda
Feb 27, 2015·Journal of Glaucoma·Shawn M IversonDavid S Greenfield
Jun 27, 2015·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Makoto AiharaKazuhiko Unoki
Aug 1, 2015·Clinical Ophthalmology·Tomoko NaitoFumio Shiraga
Nov 4, 2015·Ophthalmology·Tianjing LiKay Dickersin
Feb 11, 2016·Advances in Therapy·Tomoko NaitoKeiji Yoshikawa
May 18, 2016·European Journal of Pharmacology·Masamichi FukudaHiroshi Sasaki