Multicenter randomized trial of arsenic trioxide and Realgar-Indigo naturalis formula in pediatric patients with acute promyelocytic leukemia: Interim results of the SCCLG-APL clinical study

American Journal of Hematology
Ming-Hua YangXue-Qun Luo

Abstract

Intravenous arsenic trioxide (ATO) has been adopted as the first-line treatment for acute promyelocytic leukemia (APL). Another arsenic compound named the Realgar-Indigo naturalis formula (RIF), an oral traditional Chinese medicine containing As4 S4 , has been shown to be highly effective in treating adult APL. In the treatment of pediatric APL, the safety and efficacy of RIF remains to be confirmed. This randomized, multicenter, and noninferiority trial was conducted to determine whether intravenous ATO can be substituted by oral RIF in the treatment of pediatric APL. From September 2011 to January 2017, among 92 patients who were 16 years old or younger with newly diagnosed PML-RARa positive APL, 82 met eligible criteria and were randomly assigned to ATO (n = 42) or RIF (n = 40) group. The remaining 10 patients did not fulfilled eligible criteria because five did not accept randomization, four died and one had hemiplegia prior to arsenic randomization due to intracranial hemorrhage or cerebral thrombosis. Induction and consolidation treatment contained ATO or RIF, all-trans-retinoic acid and low intensity chemotherapy. End points included event-free survival (EFS), adverse events and hospital days. After a median 3-year follo...Continue Reading

References

Mar 27, 2004·Proceedings of the National Academy of Sciences of the United States of America·Zhi-Xiang ShenZhu Chen
Mar 18, 2008·Proceedings of the National Academy of Sciences of the United States of America·Lan WangZhu Chen
Feb 20, 2009·Proceedings of the National Academy of Sciences of the United States of America·Jiong HuZhu Chen
Jan 12, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Miguel A Sanz, Francesco Lo-Coco
Jul 12, 2013·The New England Journal of Medicine·Francesco Lo-CocoUNKNOWN Study Alliance Leukemia
Oct 16, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hong-Hu ZhuXiao-Jun Huang
Jun 8, 2014·Best Practice & Research. Clinical Haematology·Matthew A KutnyJames H Feusner
Dec 4, 2014·The New England Journal of Medicine·Hong-Hu Zhu, Xiao-Jun Huang
Sep 19, 2015·The Lancet Oncology·Alan K BurnettUNKNOWN UK National Cancer Research Institute Acute Myeloid Leukaemia Working Group
Dec 22, 2015·British Journal of Haematology·Francesco Lo-CocoMassimo Breccia
Jan 14, 2016·Current Opinion in Hematology·Simon ManthaGerald A Soff
Apr 17, 2016·Annals of Oncology : Official Journal of the European Society for Medical Oncology·L Cicconi, F Lo-Coco
Jul 13, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Uwe PlatzbeckerFrancesco Lo-Coco
Aug 23, 2016·British Journal of Haematology·Hong-Hu ZhuXiao-Jun Huang
Dec 4, 2016·Hematology·Sameem Abedin, Jessica K Altman
Dec 4, 2016·Hematology·Gert Ossenkoppele, Gerrit Jan Schuurhuis

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Citations

Jun 26, 2020·Technology in Cancer Research & Treatment·Natthaporn SasijareonratWeerapat Owattanapanich
Sep 10, 2020·Drug Development and Industrial Pharmacy·Xiao LiuYanyan Jiang
Jan 15, 2021·International Journal of Molecular Sciences·Carmelo GurnariLuisa Strocchio
Mar 7, 2021·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Lei FanXiaobo Wang
Jun 3, 2021·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Huyong ZhengUNKNOWN Chinese Children's Leukemia Group
Jul 2, 2021·Blood Cancer Journal·Musa YilmazFarhad Ravandi
Aug 9, 2021·Chinese Medicine·Qichao HuYanLing Zhao

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NCT02200978

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SPSS

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