Multicenter Selective Lymphadenectomy Trial-I confirms the central role of sentinel node biopsy in contemporary melanoma management: response to 'No survival benefit for patients with melanoma undergoing sentinel lymph node biopsy: critical appraisal of the Multicenter Selective Lymphadenectomy Trial-I final report'

The British Journal of Dermatology
Mark FariesJ F Thompson

Abstract

Sentinel lymph node (SLN) biopsy has become a standard procedure for many patients with melanoma and is recommended in numerous national and professional melanoma guidelines. The Multicenter Selective Lymphadenectomy Trial (MSLT-1) confirms earlier large database studies and prospective clinical trials in demonstrating the independent and unequalled prognostic value of the SLN. It also demonstrates the ability of biopsy-directed management to provide effective regional disease control with the least possible morbidity. These benefits are not in question and provide ample justification for the procedure, even without evidence of a survival benefit. However, MSLT-1 also provides strong evidence of a substantial reduction in the risk of melanoma death for patients with intermediate thickness melanomas who harbour occult nodal metastases at the time of presentation. Denying appropriately selected patients with melanoma the opportunity to undergo SLN biopsy is no longer reasonable or acceptable.

References

Jun 29, 2004·Journal of Surgical Oncology·Kelly M McMastersUNKNOWN Sunbelt Melanoma Trial
Nov 18, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Charles M BalchVernon K Sondak
Sep 23, 2010·British Journal of Cancer·A MitraJ A Newton-Bishop
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Feb 14, 2014·The New England Journal of Medicine·Donald L MortonUNKNOWN MSLT Group
May 30, 2014·The New England Journal of Medicine·John F ThompsonMark B Faries

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Citations

Mar 18, 2015·The British Journal of Dermatology·J M McGregor, P Sasieni
May 30, 2016·Journal of the American College of Surgeons·David Y LeeMark B Faries
Dec 5, 2008·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·H P A M PoosH J Hoekstra
Mar 21, 2007·Gynecologic Oncology·J HauspyA Covens
Sep 1, 2016·Journal of the European Academy of Dermatology and Venereology : JEADV·F Costa SvedmanJ Hansson
Jan 24, 2018·The British Journal of Dermatology·T Wiesner, A Zbyszewski
Oct 25, 2017·The Australasian Journal of Dermatology·Samuel ZagarellaPeter Heenan
Jun 16, 2017·Lymphatic Research and Biology·Philipp RennerMarc H Dahlke
Feb 27, 2019·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Anthony M RossiIan A Maher
Feb 7, 2019·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Todd V CarteeIan A Maher
Jan 25, 2020·Cancer Immunology, Immunotherapy : CII·Alyss V RobinsonRyckie G Wade
Mar 22, 2021·Otolaryngologic Clinics of North America·Vivian F Wu, Kelly M Malloy
Feb 11, 2020·Bulletin du cancer·Nadjla Alsadoun, Mojgan Devouassoux-Shisheboran

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