Multicenter study of carbon-ion radiation therapy for nonsquamous cell carcinomas of the oral cavity

Cancer Medicine
Hiroaki IkawaTadashi Kamada

Abstract

The aim of this study was to evaluate the efficacy and safety of carbon-ion radiation therapy for nonsquamous cell carcinomas of the oral cavity in a multicenter study. Retrospective analysis of the clinicopathological features and outcomes of 76 patients with oral nonsquamous cell carcinomas with N0-1 M0 status and were treated with carbon-ion radiation therapy at four institutions in Japan between November 2003 and December 2014 was performed. Salivary gland carcinoma, mucosal melanoma, and three other carcinomas were found in 46, 27, and 3 patients, respectively. T1-3, T4a, and T4b disease was diagnosed in 27, 18, and 31 patients, respectively. Median follow-up period was 31.1 months (range, 3-118 months). Three-year local control, progression-free survival, and overall survival of all patients were 86.8%, 63.1%, and 78.4%, respectively. Multivariate analysis showed T classification (T4) to be a significant independent poor prognostic factor for local control. Acute grade 3 mucositis was observed in 38 patients. Grades 3 and 4 late morbidities were observed in 9 and 4 patients, respectively. No grade 5 late toxicity was observed. Oral nonsquamous cell carcinomas could be treated effectively, with acceptable toxicity, by carb...Continue Reading

References

Jun 15, 1995·International Journal of Radiation Oncology, Biology, Physics·M H MaorL W Davis
Mar 4, 2000·International Journal of Radiation Oncology, Biology, Physics·J G DouglasT W Griffin
Jan 5, 2002·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Morten Schiødt, Niels Ulrich Hermund
Nov 24, 2004·International Journal of Oral and Maxillofacial Surgery·N TanakaT Amagasa
Nov 13, 2007·Oral Oncology·C CopelliE Sesenna
Mar 11, 2008·Oral Oncology·J P AgarwalS K Shrivastava
Mar 11, 2008·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Kouji KatsuraTakafumi Hayashi
Apr 24, 2009·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Thomas MückeFrank Hölzle
Apr 30, 2013·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·M-W HuangJ-G Zhang
Feb 11, 2015·The Journal of Craniofacial Surgery·Alimujiang Wushou, Ya-Jun Zhao
Dec 29, 2016·Journal of Radiation Research·Kensuke NaganawaUNKNOWN Organizing Committee for the Working Group for Head-and-Neck Cancer
Mar 24, 2017·International Journal of Radiation Oncology, Biology, Physics·Masashi KotoUNKNOWN Japan Carbon-Ion Radiation Oncology Study Group
May 6, 2017·Cancer Science·Katsuyuki ShiraiUNKNOWN Japan Carbon-Ion Radiation Oncology Study Group
Jun 10, 2017·Journal of the National Comprehensive Cancer Network : JNCCN·Robert J MotzerRashmi Kumar
Sep 6, 2017·International Journal of Radiation Oncology, Biology, Physics·Jun-Ichi SaitohUNKNOWN Japan Carbon-Ion Radiation Oncology Study Group
Sep 9, 2017·Clinical, Cosmetic and Investigational Dermatology·Adam K Karlsson, Sohag N Saleh
Feb 8, 2018·International Journal of Radiation Oncology, Biology, Physics·Nor Shazrina SulaimanUNKNOWN Japan Carbon-Ion Radiation Oncology Study Group
Jan 25, 2019·Head & Neck·Hiroaki IkawaTadashi Kamada

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Citations

Mar 3, 2020·Frontiers in Oncology·Timothy D MalouffDaniel Michael Trifiletti
Jan 5, 2021·Current Opinion in Otolaryngology & Head and Neck Surgery·Sara RonchiEster Orlandi
Jun 21, 2021·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Atsushi MushaTatsuya Ohno

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