Multicenter Study of Cronobacter sakazakii Infections in Humans, Europe, 2017

Emerging Infectious Diseases
Sarah LepuschitzEUCRONI Study Group

Abstract

Cronobacter sakazakii has been documented as a cause of life-threating infections, predominantly in neonates. We conducted a multicenter study to assess the occurrence of C. sakazakii across Europe and the extent of clonality for outbreak detection. National coordinators representing 24 countries in Europe were requested to submit all human C. sakazakii isolates collected during 2017 to a study center in Austria. Testing at the center included species identification by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry, subtyping by whole-genome sequencing (WGS), and determination of antimicrobial resistance. Eleven countries sent 77 isolates, including 36 isolates from 2017 and 41 historical isolates. Fifty-nine isolates were confirmed as C. sakazakii by WGS, highlighting the challenge of correctly identifying Cronobacter spp. WGS-based typing revealed high strain diversity, indicating absence of multinational outbreaks in 2017, but identified 4 previously unpublished historical outbreaks. WGS is the recommended method for accurate identification, typing, and detection of this pathogen.

References

Jan 16, 2004·Lancet·M Chantal KandhaiMike van Schothorst
Jan 7, 2005·Journal of Food Protection·A Lehner, R Stephan
Mar 3, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D DrudyS Fanning
Sep 6, 2011·Emerging Infectious Diseases·Susan Joseph, Stephen J Forsythe
Apr 18, 2012·Journal of Computational Biology : a Journal of Computational Molecular Cell Biology·Anton BankevichPavel A Pevzner
Dec 18, 2013·The Journal of Hospital Infection·O Holý, S Forsythe
Feb 27, 2014·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Andrea MüllerAngelika Lehner
Aug 26, 2014·Emerging Infectious Diseases·Mary E PatrickAnna Bowen
Jun 4, 2015·Journal of Food Protection·Emily E JacksonStephen J Forsythe
Jun 14, 2015·Applied and Environmental Microbiology·Martina BlažkováLadislav Fukal
Jul 16, 2015·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·A AlsonosiO Holý
Oct 30, 2016·Nucleic Acids Research·Baofeng JiaAndrew G McArthur
Dec 23, 2017·Annual Review of Food Science and Technology·Stephen J Forsythe
Jul 20, 2018·Journal of Pediatric Gastroenterology and Nutrition·Marina Nadia LosioStefano Cinotti
Sep 19, 2018·Emerging Infectious Diseases·Cláudia Elizabeth Volpe ChavesAnamaria Mello Miranda Paniago

❮ Previous
Next ❯

Citations

Jul 9, 2020·Foods·Muhammad Tanveer Munir, Michel Federighi
Mar 27, 2020·Frontiers in Microbiology·Amal A ElkhawagaMohamed A El-Mokhtar
Oct 23, 2020·Journal of Applied Microbiology·P V CostaM L Lima Brandão
Dec 19, 2020·Comprehensive Reviews in Food Science and Food Safety·Vincenzina FuscoCharles M A P Franz
Apr 3, 2021·BMC Women's Health·Satoshi OhiraRyota Tachibana
May 29, 2021·BMC Infectious Diseases·Syeda SahraMuhammad Ans Sharif
Jul 16, 2021·Microbiology Resource Announcements·Julio Parra-FloresStephen Forsythe
Nov 26, 2020·Food Research International·Gabriela Guimarães CarvalhoDirce Yorika Kabuki
Nov 26, 2020·Food Research International·Rajni ChauhanGunjan Goel

❮ Previous
Next ❯

Datasets Mentioned

BETA
BAA-894

Methods Mentioned

BETA
whole-genome shotgun sequencing

Software Mentioned

SeqSphere
SPAdes
Sequencing Coverage Calculator
JSpeciesWS

Related Concepts

Related Feeds

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.