Multicenter Study of Intense Pulsed Light Therapy for Patients With Refractory Meibomian Gland Dysfunction

Cornea
Reiko AritaNaoyuki Morishige

Abstract

To evaluate the efficacy of intense pulsed light (IPL) therapy combined with meibomian gland expression (MGX) for refractory meibomian gland dysfunction (MGD) in a prospective study conducted at 3 sites in Japan. Patients with refractory obstructive MGD were enrolled and underwent 4 to 8 IPL-MGX treatment sessions at 3-week intervals. Clinical assessment included the Standard Patient Evaluation of Eye Dryness questionnaire; noninvasive breakup time of the tear film and interferometric fringe pattern as determined by tear interferometry; lid margin abnormalities, fluorescein breakup time of the tear film, corneal and conjunctival fluorescein staining (CFS), and meibum grade as evaluated with a slit-lamp microscope; meibomian gland morphology (meiboscore); and tear production as measured by the Schirmer test without anesthesia. Sixty-two eyes of 31 patients (17 women, 14 men; mean age ± SD, 47.6 ± 16.8 years) were enrolled. The Standard Patient Evaluation of Eye Dryness score (P < 0.001), noninvasive breakup time (P < 0.001), and interferometric fringe pattern (P < 0.001) were significantly improved after therapy, with 74% of eyes showing a change in the interferometric fringe pattern from 1 characteristic of lipid deficiency to ...Continue Reading

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Citations

Dec 14, 2019·Eye & Contact Lens·Pun Yuet LamLouis Tong
Jul 25, 2020·The British Journal of Ophthalmology·Pasquale AragonaMaurizio Rolando
Jan 10, 2020·International Ophthalmology·Serap Yurttaser OcakMustafa Elcioglu
Jan 17, 2020·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Reiko Arita, Shima Fukuoka
Feb 5, 2021·Clinical Ophthalmology·Samantha SagaserJoanne F Shen
Apr 25, 2021·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Yana FuXiuMing Jin
Jul 9, 2021·Clinical Ophthalmology·Ana MartaIrene Barbosa
Mar 22, 2020·Archivos de la Sociedad Española de Oftalmología·G Fuentes PáezS Burillo
Sep 21, 2021·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Siamak Zarei-GhanavatiElham Bakhtiari

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