Multicenter Study of Metastatic Lung Tumors Targeted by Interventional Cryoablation Evaluation (SOLSTICE).

Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer
Matthew R CallstromThierry de Baere

Abstract

To assess the safety and local recurrence-free survival in patients after cryoablation for treatment of pulmonary metastases. This multicenter, prospective, single-arm, phase 2 study included 128 patients with 224 lung metastases treated with percutaneous cryoablation, with 12 and 24 months of follow-up. The patients were enrolled on the basis of the outlined key inclusion criteria, which include one to six metastases from extrapulmonary cancers with a maximal diameter of 3.5 cm. Time to progression of the index tumor(s), metastatic disease, and overall survival rates were estimated using the Kaplan-Meier method. Complications were captured for 30 days after the procedure, and changes in performance status and quality of life were also evaluated. Median size of metastases was 1.0 plus or minus 0.6 cm (0.2-4.5) with a median number of tumors of 1.0 plus or minus 1.2 cm (one to six). Local recurrence-free response (local tumor efficacy) of the treated tumor was 172 of 202 (85.1%) at 12 months and 139 of 180 (77.2%) at 24 months after the initial treatment. After a second cryoablation treatment for recurrent tumor, secondary local recurrence-free response (local tumor efficacy) was 184 of 202 (91.1%) at 12 months and 152 of 180 (8...Continue Reading

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Citations

Mar 7, 2021·Cancers·Alexandre DelplaLambros Tselikas
Apr 12, 2021·The Journal of Thoracic and Cardiovascular Surgery·Mara B AntonoffQuynh-Nhu Nguyen
Apr 30, 2021·Insights Into Imaging·Alfredo Páez-CarpioIvan Vollmer
May 20, 2021·AJR. American Journal of Roentgenology·Maria M WrobelFlorian J Fintelmann
Aug 14, 2021·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Thierry de BaèreMatthew Callstrom
Sep 22, 2021·Journal of Vascular and Interventional Radiology : JVIR·Gérald GahideMaxime Noel-Lamy
Oct 7, 2021·AJR. American Journal of Roentgenology·Patrick P BourgouinFlorian J Fintelmann

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