Multicenter validation of a gene expression-based prognostic signature in lymph node-negative primary breast cancer

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
John A FoekensYixin Wang

Abstract

We previously identified in a single-center study a 76-gene prognostic signature for lymph node-negative (LNN) breast cancer patients. The aim of this study was to validate this gene signature in an independent more diverse population of LNN patients from multiple institutions. Using custom-designed DNA chips we analyzed the expression of the 76 genes in RNA of frozen tumor samples from 180 LNN patients who did not receive adjuvant systemic treatment. In this independent validation, the 76-gene signature was highly informative in identifying patients with distant metastasis within 5 years (hazard ratio, [HR], 7.41; 95% CI, 2.63 to 20.9), even when corrected for traditional prognostic factors in multivariate analysis (HR, 11.36; 95% CI, 2.67 to 48.4). The actuarial 5- and 10-year distant metastasis-free survival were 96% (95% CI, 89% to 99%) and 94% (95% CI, 83% to 98%), respectively, for the good profile group and 74% (95% CI, 64% to 81%) and 65% (53% to 74%), respectively for the poor profile group. The sensitivity for 5-yr distant metastasis-free survival was 90%, and the specificity was 50%. The positive and negative predictive values were 38% (95% CI, 29% to 47%) and 94% (95% CI, 86% to 97%), respectively. The 76-gene signa...Continue Reading

References

Jan 1, 1992·Breast Cancer Research and Treatment·M H GaleaI O Ellis
Jan 23, 1999·Nature Genetics·R J LipshutzD J Lockhart
Feb 2, 2002·Nature·Laura J van 't VeerStephen H Friend
Dec 20, 2002·The New England Journal of Medicine·Marc J van de VijverRené Bernards
Jan 2, 2003·Journal of the National Cancer Institute·Richard SimonLisa M McShane
Jan 2, 2003·Nature Genetics
May 16, 2003·Lancet·Erich HuangAndrew T Huang
Jul 9, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Aron GoldhirschHans-Jörg Senn
Aug 15, 2003·Proceedings of the National Academy of Sciences of the United States of America·Christos SotiriouEdison T Liu
Dec 14, 2004·The New England Journal of Medicine·Soonmyung PaikNorman Wolmark
Feb 1, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Maurice P H M JansenEls M J J Berns
Feb 3, 2005·Nature Reviews. Cancer·David F Ransohoff

❮ Previous
Next ❯

Citations

May 20, 2006·Der Urologe. Ausg. A·M-O GrimmR Ackermann
Sep 12, 2008·Breast Cancer Research and Treatment·Noel T BrewerBarbara K Rimer
Sep 30, 2008·Breast Cancer Research and Treatment·Yi ZhangJohn A Foekens
Dec 5, 2008·Breast Cancer Research and Treatment·Balazs Györffy, Reinhold Schäfer
May 4, 2010·Breast Cancer Research and Treatment·Barbara K DunnKaren A Johnson
Jul 16, 2010·Breast Cancer Research and Treatment·Marcel SmidJohn W M Martens
Oct 4, 2011·Breast Cancer Research and Treatment·Noel T BrewerLisa A Carey
Nov 9, 2012·Breast Cancer Research and Treatment·Karin Milde-LangoschRalph M Wirtz
Nov 2, 2007·Clinical & Experimental Metastasis·Keltouma DriouchRosette Lidereau
Apr 7, 2009·Clinical & Experimental Metastasis·Kent W Hunter, Jude Alsarraj
Mar 25, 2009·Clinical & Experimental Metastasis·Ulrich PfefferAdriana Albini
Apr 22, 2009·Clinical & Experimental Metastasis·Attila TordaiLajos Pusztai
Apr 28, 2007·Reviews in Endocrine & Metabolic Disorders·Shannon R Morris, Lisa A Carey
Dec 17, 2009·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Yoshio Miki
Nov 3, 2006·Nature Clinical Practice. Oncology·Fabrice Andre, Lajos Pusztai
Aug 8, 2006·Nature Medicine·Larry Norton, Joan Massagué
Jun 23, 2007·Nature Reviews. Cancer·Christos Sotiriou, Martine J Piccart
Feb 6, 2013·Nature Reviews. Clinical Oncology·François-Clément BidardJean Paul Thiery
Feb 21, 2009·The New England Journal of Medicine·Christos Sotiriou, Lajos Pusztai
Aug 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·John A FoekensJohn W M Martens
Mar 31, 2009·Molecular & Cellular Proteomics : MCP·Arzu UmarLjiljana Pasa-Tolić
Jan 20, 2007·Omics : a Journal of Integrative Biology·François BertucciDaniel Birnbaum
Oct 15, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S MookL J van 't Veer
Apr 12, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·O BrouckaertP Neven
Feb 6, 2007·Bioinformatics·Monica NicolauStefanie S Jeffrey
Sep 7, 2006·Journal of the National Cancer Institute·Marc BuyseUNKNOWN TRANSBIG Consortium
Nov 15, 2007·Journal of the National Cancer Institute·Lara LusaMarco A Pierotti
Dec 17, 2009·Journal of the National Cancer Institute·M AnsemsGosse J Adema
Jan 6, 2009·Critical Care Medicine·Carolyn StraehleMartine J Piccart-Gebhart
Mar 24, 2011·The Cancer Journal·Natalie GalaninaLyndsay N Harris
Oct 3, 2006·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·J HellemanE M J J Berns
Jan 25, 2013·Science Translational Medicine·Raheleh HatamiGoutham Narla
Jul 28, 2009·Annual Review of Medicine·Phuong Khanh H Morrow, Gabriel N Hortobagyi
Nov 28, 2007·Annual Review of Pathology·Maggie C U CheangTorsten O Nielsen
Mar 6, 2012·BMC Genomics·Chang ChangTieliu Shi
Aug 23, 2008·BMC Genomics·Benjamin Haibe-KainsChristos Sotiriou
Jun 15, 2013·BMC Cancer·Frank A W CoumansLeon W M M Terstappen
Apr 3, 2007·Breast Cancer Research : BCR·Lance D Miller, Edison T Liu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

© 2021 Meta ULC. All rights reserved