Multicenter Validation of the DETAIL Questionnaire for the Screening of Spondyloarthritis in Patients With Inflammatory Bowel Diseases.

The Journal of Rheumatology
Devis BenfaremoGRADES-IBD Study Group

Abstract

Spondyloarthritis (SpA) is among the most frequent extraintestinal manifestations of inflammatory bowel diseases (IBD). In this study, we aimed to validate the DETection of Arthritis in Inflammatory boweL diseases (DETAIL) questionnaire in a multicenter cohort of patients with IBD enrolled at 11 gastroenterology units. From October 2018 to March 2019, consecutive adult patients with IBD, either Crohn disease or ulcerative colitis, independently filled out the DETAIL questionnaire in the outpatient waiting room. Within 2 weeks a blinded rheumatologist assessed all the patients, irrespective of the DETAIL results, and classified them to be affected or not by SpA. The performance of the questions was evaluated through Bayesian analysis. Overall, 418 patients with IBD filled out the DETAIL questionnaire. Upon rheumatological evaluation, 102 (24.4%) patients received a diagnosis of SpA. Of the 6 questions, the best performances were found in question 6 [positive likelihood ratio (LR)+ 3.77], reporting inflammatory back pain at night, and in question 3 (LR+ 3.31), exploring Achilles enthesitis. The presence of back pain lasting > 3 months (LR+ 2.91), back pain with inflammatory features (LR+ 2.55), and a history of dactylitis (LR+ 2....Continue Reading

References

Apr 26, 2007·Annals of the Rheumatic Diseases·Henning Christian BrandtJoachim Sieper
Mar 13, 2009·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·R D'IncàG C Sturniolo
Nov 26, 2009·World Journal of Gastroenterology : WJG·Tatiana Sofía Rodríguez-ReynaJesús Kazúo Yamamoto-Furusho
Nov 12, 2015·Autoimmunity Reviews·Paola ConigliaroLivia Biancone
Jan 8, 2017·Rheumatology International·Marco Di CarloFausto Salaffi
Nov 3, 2017·World Journal of Gastroenterology : WJG·Michele Maria LuchettiArmando Gabrielli
Dec 27, 2017·Current Pharmaceutical Biotechnology·Michele M LuchettiArmando Gabrielli
Oct 26, 2018·Scandinavian Journal of Gastroenterology·Alvilde Maria OssumUNKNOWN IBSEN study group
Nov 1, 2018·Rheumatology·Nicolas IragorriEldon Spackman
Nov 15, 2018·Inflammatory Bowel Diseases·Orlaith B KellyMark S Silverberg
May 31, 2019·World Journal of Gastroenterology : WJG·George E FragoulisTheodoros Dimitroulas
Jul 6, 2019·Journal of Immunology Research·Devis BenfaremoArmando Gabrielli

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