PMID: 15365303Sep 15, 2004Paper

Multicenter validation study of the %CDT TIA kit in alcohol abuse and alcohol dependence

Alcoholism, Clinical and Experimental Research
Raymund SchwanMichel Reynaud

Abstract

Carbohydrate-deficient transferrin (CDT) and gamma-glutamyl transferase (GGT) are used as biomarkers of alcohol misuse. The aim of this study was to evaluate, in terms of sensitivity and specificity, the performance of the new Bio-Rad %CDT TIA kit and GGT assay for identifying alcohol abuse and alcohol dependence (according to the DSM-IV criteria). An open multicenter study (30 centers) over 3 months, including patient groups of "abusers," "dependents," and controls, was conducted in France. In alcohol abuse, the sensitivity of GGT was 0.56, and that of CDT was 0.80; in alcohol dependence, the sensitivity of GGT was 0.86, and that of CDT was 0.91. The specificity of GGT was 0.77, and that of CDT was 0.83. The association of GGT with CDT increased sensitivity for alcohol abuse to 0.90 and for alcohol dependence to 0.99, but it appreciably decreased specificity (0.63). %CDT is the better screening marker for alcohol abuse and dependence, but GGT is still a useful marker for the detection of alcohol dependence. As an assay method, the second-generation Bio-Rad %CDT immunoassay can be recommended for routine CDT measurement.

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Citations

May 20, 2005·The New England Journal of Medicine·Raymund Schwan, John P Allen
Aug 1, 2008·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·François SchellenbergJean Christophe Pagès
Jun 29, 2007·European Psychiatry : the Journal of the Association of European Psychiatrists·Renaud de BeaurepaireRobert Molimard
Dec 1, 2012·Journal of Separation Science·Jitka Caslavska, Wolfgang Thormann
Aug 17, 2005·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·François SchellenbergMichel Reynaud
Jan 18, 2005·Alcoholism, Clinical and Experimental Research·Raymund SchwanPierre-Michel Llorca
Jun 27, 2006·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Johanna HietalaOnni Niemelä
Sep 9, 2017·Journal of Separation Science·Jitka Caslavska, Wolfgang Thormann

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