PMID: 3908126Jan 1, 1985Paper

Multicentre comparison of the antihypertensive effect of acebutolol and hydrochlorothiazide in uncomplicated mild-moderate hypertension in the elderly

European Journal of Clinical Pharmacology
A SalvettiG Pettinà


To evaluate the efficacy of acebutolol, 400-600 mg/day in elderly hypertensive patients, and to compare it with hydrochlorothiazide 25-50 mg/day, 45 patients with mild-moderate uncomplicated hypertension were treated for 6 weeks in a multicentre, single-blind, randomized, crossover trial. Acebutolol decreased supine systolic blood pressure from 186.5 to 162.7 mmHg and diastolic blood pressure from 107.4 to 92.4 mmHg. Hydrochlorothiazide decreased systolic blood pressure from 185.0 to 166.4 and diastolic blood pressure from 107.2 to 96.4. There was no difference between the effects of acebutolol and hydrochlorothiazide on blood pressure during the trial. Both drugs proved to be safe and effective antihypertensive agents, provided the major contraindications for their use were taken into account. Beta-blockade by acebutolol was highly effective in treating mild-moderate arterial hypertension in the elderly.


Nov 1, 1977·Clinical Pharmacology and Therapeutics·M G TweeddaleJ Ruedy
Oct 14, 1977·European Journal of Clinical Pharmacology·L HanssonM Holm
Jul 1, 1979·British Journal of Clinical Pharmacology·M Hills, P Armitage
Oct 19, 1972·The New England Journal of Medicine·W B KannelM Feinleib
May 1, 1974·American Journal of Public Health·A M OstfeldH M Tufo
Sep 1, 1970·Clinical Pharmacology and Therapeutics·P J McLeodJ Ruedy
Apr 1, 1971·The American Journal of Cardiology·W B KannelM J Schwartz
May 1, 1980·Clinical Pharmacology and Therapeutics·M J SerlinA Breckenridge
Oct 1, 1983·British Journal of Clinical Pharmacology·W G O'CallaghanK O'Malley
Nov 10, 1983·The American Journal of Cardiology·S H Taylor
Mar 9, 1984·JAMA : the Journal of the American Medical Association·I HolmeP G Lund-Larsen

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