Abstract
No effective treatment is currently available to prevent progression of small and medium-sized abdominal aortic aneurysms (AAAs). Identification of drugs with sufficient promise to justify large expensive randomized trials remains challenging. One potentially useful strategy is to look for associations between commonly used drugs and AAA enlargement in appropriately adjusted observational studies. Potential AAA measurements were identified from abdominal imaging reports in the electronic data files of three medical centres from 1995 to 2010. AAA measurements were extracted manually and patients with an aneurysm of 3 cm or larger, who had at least two measurements over an interval of at least 6 months, were identified. Other data were obtained from the electronic data files (demographics, co-morbidities, smoking status, drug use) to conduct a propensity analysis of the associations of drugs and other factors with AAA enlargement. From 52,962 abdominal imaging studies, 5362 patients with an AAA of 3 cm or more were identified, of whom 2428 had at least two measurements over at least 6 months. Mean AAA follow-up was 3.4 years and the mean AAA enlargement rate was 2.0 mm per year. Propensity analysis demonstrated no significant ass...Continue Reading
References
Aug 1, 1988·Medical Care·J F SteinerT S Inui
Jun 1, 1995·Journal of Vascular Surgery·F A LederleH J Ansel
Jan 1, 1997·Journal of Clinical Epidemiology·J F Steiner, A V Prochazka
Aug 28, 1999·Journal of Clinical Epidemiology·C van WalravenA Laupacis
Jan 22, 2002·Journal of Vascular Surgery·UNKNOWN Propanolol Aneurysm Trial Investigators
May 10, 2002·The New England Journal of Medicine·Frank A LederleUNKNOWN Aneurysm Detection and Management Veterans Affairs Cooperative Study Group
May 23, 2002·The Annals of Pharmacotherapy·Amy J WannemacherKevin A Townsend
Feb 3, 2005·Annals of Internal Medicine·UNKNOWN U.S. Preventive Services Task Force
May 21, 2011·Atherosclerosis·Jonathan Golledge, Paul E Norman
Jan 13, 2012·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·F A Lederle
Mar 6, 2012·The British Journal of Surgery·M J SweetingUNKNOWN RESCAN collaborators
Mar 16, 2012·The Cochrane Database of Systematic Reviews·Giovanni FilardoDavid J Ballard
Nov 24, 2012·International Journal of Cardiology·Hisato TakagiUNKNOWN All-Literature Investigation of Cardiovascular Evidence Group
Feb 4, 2014·Annals of Internal Medicine·Frank A Lederle
Nov 13, 2014·JAMA Surgery·Rachel H BhakUNKNOWN Aneurysm Detection and Management (ADAM) Study Group
Citations
Feb 5, 2016·Vascular Medicine·Hisato TakagiUNKNOWN ALICE (All-Literature Investigation of Cardiovascular Evidence) Group
Oct 6, 2017·Journal of Thrombosis and Thrombolysis·Talha ButtStefan Acosta
Jan 26, 2018·Journal of the American Heart Association·Tarik AvdicBjörn Eliasson
Jan 8, 2017·Arteriosclerosis, Thrombosis, and Vascular Biology·Jean SénémaudRaphaël Coscas
Aug 30, 2017·The Journal of Cardiovascular Surgery·Carsten Behr-AndersenJes S Lindholt
Mar 7, 2019·Journal of Biomechanical Engineering·Hannah CebullCraig Goergen
Apr 11, 2020·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·S Scott SuttonJames W Hardin
Jul 30, 2020·European Heart Journal. Cardiovascular Pharmacotherapy·Maria Lukács KrogagerDeepak L Bhatt
Aug 4, 2019·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Satoshi UmemuraNobuhito Hirawa
Jul 10, 2019·Cardiovascular Research·Begoña LavinAlkystis Phinikaridou
May 27, 2020·JAMA : the Journal of the American Medical Association·B Timothy BaxterUNKNOWN N-TA3CT Investigators
Oct 30, 2018·Journal of the American Heart Association·Konrad SalataMohammed Al-Omran
Aug 24, 2019·Vascular Medicine·Soumia TaimourAnders Gottsäter
Jul 2, 2020·Vascular Health and Risk Management·Siong Teng SawDayang Anita Abdul Aziz
Feb 9, 2018·Oncotarget·Jen-Chun WangShih-Hung Tsai
Aug 31, 2019·European Journal of Preventive Cardiology·Ashfaque A MemonKristina Sundquist
Feb 7, 2021·Journal of Vascular Surgery·Myra McLenonRobert W Chang
Jan 19, 2021·Journal of Atherosclerosis and Thrombosis·Shunsuke KatsukiKensuke Egashira
Apr 25, 2021·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·Marine GaudryLaurence Bal
Mar 18, 2017·Annals of Vascular Surgery·Chien Yi M PngPeter L Faries
Jul 2, 2021·Journal of Vascular Surgery·Xiaowei XiongXinwu Lu
Oct 26, 2021·Journal of Vascular Surgery·Matthew J NordnessJohn A Curci
Mar 10, 2019·Journal of Vascular Surgery·Johannes StegbauerLisa A Cassis
Oct 23, 2018·Journal of Vascular Research·Chia-Ching HsuShih-Hung Tsai