PMID: 591535Dec 1, 1977

Multicentric giant-cell tumor of bone

The Journal of Bone and Joint Surgery. American Volume
F H SimJ W Beabout


The presence of more than one distinct giant-cell tumor in the same patient is rare; seven cases have been reported in the literature. The present series involves eleven patients with thirty-five individual tumors. Multifocal giant-cell tumors may pose a diagnostic problem. It is difficult to distinguish a multicentric giant-cell tumor from a primary giant-cell tumor with metastatic spread. This problem is magnified when the second lesion is not noted at the onset or is metaphyseal in location. Moreover, these lesions present a therapeutic challenge to the surgeon. Multiple lesions tend to exhibit the same aggressive clinical behavior as a solitary giant-cell tumor. A high recurrence rate after curettage indicates that aggressive surgical management is necessary.

Related Concepts

Malignant Bone Neoplasm
Giant Cell Tumors
Neoplasms, Multiple Primary

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