PMID: 11932891Apr 5, 2002Paper

Multicentric mammary carcinoma: evidence of monoclonal proliferation

Cancer
Lavinia MiddletonAysegul A Sahin

Abstract

Both the widespread use of screening mammography and emphasis on breast conservation have raised many questions regarding the clinical and therapeutic management of multicentric mammary carcinoma (MMC). MMC has been postulated to be either a clonal proliferation of a single mammary carcinoma or multiple independent synchronous primary tumors in the same breast. The goal of the current study was to evaluate the histologic features and immunohistochemical profile of MMC. We also compared the clinical outcomes of the patients in the current study with stage-matched and treatment-matched groups of patients with unicentric mammary carcinoma. The authors studied 32 patients with T1-T2, N0-1, M0 multicentric invasive mammary carcinomas diagnosed between 1983-1988 and treated at The University of Texas M. D. Anderson Cancer Center. The histologic features of each tumor (including tumor type, nuclear grade, presence of in situ carcinoma, pattern of in situ carcinoma, and lymphovascular invasion) were evaluated. The authors performed immunohistochemical analysis of estrogen receptor (ER), progesterone receptor (PR), HER-2/neu, and Ki-67 in 25 cases, including 14 from which > 1 tumor was available to perform comparative immunohistochemica...Continue Reading

References

Jan 1, 1987·Journal of Cancer Research and Clinical Oncology·J LüttgesP Prinz
Apr 1, 1981·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S M HsuH Fanger
Sep 1, 1995·Human Pathology·P J DawsonR A Clark
Mar 1, 1993·American Journal of Clinical Pathology·O AnastassiadesA Karameris
Sep 1, 1996·British Journal of Cancer·J S VaidyaI Mittra
Sep 27, 2000·Annals of Surgical Oncology·G VlastosS E Singletary

❮ Previous
Next ❯

Citations

Nov 17, 2010·Breast Cancer Research and Treatment·R EelesJ Yarnold
Jan 27, 2011·Cancer Metastasis Reviews·Dieter HölzelJutta Engel
Jun 5, 2004·The Breast : Official Journal of the European Society of Mastology·L PedersenC Lanng
May 25, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·H G MoonD Y Noh
Sep 9, 2008·Applied Immunohistochemistry & Molecular Morphology : AIMM·Ying CaoConstance T Albarracin
Oct 6, 2004·Journal of Carcinogenesis·Dominik WodarzNatalia L Komarova
May 1, 2013·Archives of Pathology & Laboratory Medicine·Oleksandr N KryvenkoJonathan I Epstein
Jun 15, 2014·Breast Cancer Research and Treatment·Francisco E Vera-BadilloEitan Amir
Oct 12, 2013·American Journal of Surgery·Hüseyin KadioğluMahmut Müslümanoğlu
Jan 6, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·F BuggiL Serra
Jul 10, 2010·Surgical Oncology·Sofiane BendifallahRoman Rouzier
Jan 31, 2009·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Mariella Mannino, John Yarnold
Aug 12, 2008·The Breast : Official Journal of the European Society of Mastology·L E JoergensenB B Rasmussen
Jan 21, 2014·The Breast Journal·Nüvit Duraker, Zeynep Civelek Caynak
May 26, 2004·Pathology, Research and Practice·Antonio CavaliereAngelo Sidoni
Jan 28, 2003·Cancer·Manuel R TeixeiraSverre Heim
Mar 26, 2015·Annals of Surgical Oncology·Prathima KanumuriDonald R Lannin
Jul 30, 2014·Seminars in Cancer Biology·Roberto SalgadoChristine Desmedt
Jan 15, 2016·Applied Immunohistochemistry & Molecular Morphology : AIMM·Monica BorosSimona Stolnicu
Oct 5, 2007·International Journal of Surgical Pathology·Tibor Tot
Sep 8, 2018·Archives of Pathology & Laboratory Medicine·Pooja NavaleAnupma Nayak
Jun 15, 2007·Acta Oncologica·Anders Husted MadsenPeer Christiansen
Sep 21, 2013·American Journal of Clinical Pathology·Gillian C BethuneMartin C Chang
Dec 20, 2019·Journal of Magnetic Resonance Imaging : JMRI·Hui WangKenneth G A Gilhuijs
Jan 14, 2020·British Journal of Cancer·Soomin AhnSo Yeon Park
Dec 4, 2012·International Journal of Surgical Pathology·Melike PekmezciÇağatay Erşahin
Jun 15, 2011·Human Pathology·Tibor TotLászló Tabár
Aug 1, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·F BuggiL Serra
Jan 3, 2021·Clinical Breast Cancer·Jessie M Wu, Gulisa Turashvili

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Ductal

Ductal carcinoma is a malignant neoplasm involving the ductal systems of any of a number of organs, such as the mammary glands, pancreas, prostate or lacrimal gland. Discover the latest research on ductal carcinoma here.

Carcinoma, Lobular

Lobular carcinoma is an invasive type of breast cancer in which lobules, areas of the breast that produce milk, undergo malignant transformation. Here is the latest research.