Multicentric reticulohistiocytosis: a unique case with pulmonary fibrosis

Archives of Dermatology
Kelly L WestPuja K Puri

Abstract

Multicentric reticulohistiocytosis (MRH) is a rare disease of uncertain etiology that most commonly presents as a papulonodular cutaneous eruption accompanied by erosive polyarthritis. Although MRH is considered a systemic disorder in that it targets skin and joints, involvement of thoracic and visceral organs is uncommon. A woman presented with diffuse cutaneous nodules, and skin biopsy findings revealed classic features of MRH. However, she also manifested severe pulmonary symptoms. A lung biopsy specimen showed prominent histiocytic infiltrates exhibiting the same characteristic morphologic features as those seen in her skin. Furthermore, the lung biopsy findings were significant for a pattern of usual interstitial pneumonia accompanied by notable lymphoid aggregates, a pattern of interstitial lung disease typical of systemic autoimmune and inflammatory conditions. These findings are notable because a histiocytic pulmonary infiltrate suggestive of direct pulmonary involvement by MRH is a rare event. In addition, presentation of MRH in the setting of usual interstitial pneumonia is unique. These observations document a new clinical and histopathologic presentation of MRH that is significant for expanding the idea of MRH as a ...Continue Reading

Citations

Feb 19, 2013·Clinical Reviews in Allergy & Immunology·Arshia D IslamM Eric Gershwin
Oct 9, 2012·Best Practice & Research. Clinical Rheumatology·Francesco Trotta, Matteo Colina
Jan 18, 2018·Arthritis Care & Research·Sean B SingerJohn T O'Malley
Apr 16, 2014·Clinical Rheumatology·Cristina C Macía-Villa, Antonio Zea-Mendoza
Nov 23, 2013·International Journal of Dermatology·Michael M Sachse, Friedrich A Bahmer
Jan 8, 2016·Respirology Case Reports·Katsuhiro YoshimuraTakafumi Suda
Apr 23, 2015·Current Rheumatology Reports·Carlo SelmiM Eric Gershwin
Apr 24, 2021·Joint, Bone, Spine : Revue Du Rhumatisme·Yann NguyenLaure Frumholtz
Sep 22, 2021·The American Journal of Dermatopathology·Yumeng LiFabrizio Galimberti

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