Multicentric reticulohistiocytosis with generalized systemic involvement

Clinical and Experimental Dermatology
Y H Liu, K Fang

Abstract

We describe a 33-year-old woman with a 2-year history of rheumatoid arthritis-like joint changes and a 1-year history of papulonodules on the fingers, ears, oral mucosa, forearm, elbows and thighs, and erythematous plaques on the buttocks. Six months after the onset of the cutaneous lesions she had dyspnoea, 3 months later she developed a husky sound. Biopsies from the nodules on the ear and left forearm revealed multinucleated giant cells with eosinophilic 'ground-glass' cytoplasm. Bronchoscopy revealed that there were nodules in the bronchus. A biopsy taken from a nodule from the bronchus was consistent with multicentric reticulohistiocytosis. Fibrostic laryngoscopy showed a mass 1.5 x 2.0 cm(2) in size on the left aryepiglottic fold and posterior commissure. Magnetic resonance imaging revealed a large pleural effusion and pericardiac effusion. Ultrasound revealed splenomegaly and peritoneal fluid. Combination therapy with prednisone, cyclophosphamide and methotrexate significantly improved cutaneous and joint symptoms. The huge cutaneous erythematous plaques and the generalized systemic involvement make this case interesting.

References

Jan 1, 1985·Medical and Pediatric Oncology·J C NunninkJ W Yates
Apr 30, 1973·JAMA : the Journal of the American Medical Association
Jun 1, 1972·The American Journal of Medicine·G E EhrlichW A Katz
May 1, 1983·Journal of the American Academy of Dermatology·N FureyJ Shaw
Sep 1, 1980·Clinical and Experimental Dermatology·M D Catterall
Nov 1, 1993·Clinical and Experimental Dermatology·K C YeeR G Palmer
Jan 1, 1993·Clinics in Dermatology·R P Rapini
May 1, 1964·Archives of Dermatology·M ORKINI FISHER

❮ Previous
Next ❯

Citations

Oct 31, 2013·European Journal of Medical Research·Xinyan HuangSongzhao Zhang
Dec 12, 2012·Revista española de medicina nuclear e imagen molecular·D Ramírez OcañaC Puentes Zarzuela
Apr 16, 2014·Clinical Rheumatology·Cristina C Macía-Villa, Antonio Zea-Mendoza
Jan 26, 2016·The Australasian Journal of Dermatology·Janet Kim, Jonathan J Chan
Oct 9, 2012·Best Practice & Research. Clinical Rheumatology·Francesco Trotta, Matteo Colina
Jun 11, 2011·The Journal of Dermatology·Antoni BennàssarCarmen Herrero
Sep 19, 2006·Best Practice & Research. Clinical Rheumatology·Joshua Levin, Victoria P Werth
Jul 22, 2014·International Journal of Dermatology·Dong In KeumWon-Soo Lee
Jun 26, 2013·International Journal of Surgery Case Reports·Ryckie G WadeDamodar Makkuni
Apr 25, 2017·Clinical and Experimental Dermatology·C PengJ B Powell
Mar 4, 2008·Arthritis and Rheumatism·Katerine A CodrianskyEugene Y Kissin
Aug 6, 2008·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Tamika Webb-DetiegePrimal Kaur
Apr 23, 2015·Current Rheumatology Reports·Carlo SelmiM Eric Gershwin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of the American Academy of Dermatology
Melissa A BogleJohn Marshall Knox
Clinics in Dermatology
Ani L TajirianEdward V Lally
Archives of Dermatology
Bradley T KovachWilliam W Ginsburg
© 2022 Meta ULC. All rights reserved