PMID: 15330051Aug 28, 2004Paper

Multichannel mould processing of 3D structures from microporous coralline hydroxyapatite granules and chitosan support materials for guided tissue regeneration/engineering

Journal of Materials Science. Materials in Medicine
E T BaranR L Reis

Abstract

A three-dimensional composite material was produced from microporous coralline origin hydroxyapatite (HA) microgranules, chitosan fibers and chitosan membrane. Cylindrical HA microgranules were oriented along channel direction within multichannel mould space and aligned particles were supported with fibers and a chitosan membrane. The positive replica of mould channels was clasp fixed to produce thicker scaffolds. Light microphotographs of the developed complex structure showed good adhesion between the HA particles, the fibers and the supporting membrane. The composite material showed 88% (w/w) swelling in one hour and preserved the complex structure of the original material upon long-term incubation in physiological medium. MEM extract test of HA chitosan complex showed no cell growth inhibition and cell viability assay (MTS) indicated over 90% cell viability.

Citations

Jul 11, 2007·Journal of Materials Science. Materials in Medicine·Y M YangX S Gu
Dec 1, 2007·Journal of Materials Science. Materials in Medicine·A C Tas
Jul 31, 2013·Biological Trace Element Research·Yanhua WangJingcheng Zhang
Apr 2, 2013·Acta Biomaterialia·Liane I F MouraHermínio C de Sousa
Apr 11, 2014·Diagnostic Microbiology and Infectious Disease·Ana Cristina AbreuManuel Simões
Feb 7, 2007·Expert Review of Medical Devices·Thomas WeigelAndreas Lendlein

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