Multicomponent Approach to Hydantoins and Thiohydantoins Involving a Deep Eutectic Solvent

Chemistry, an Asian Journal
Sambasivarao KothaVikas R Aswar

Abstract

We report an efficient synthetic strategy to diverse hydantoins and thiohydantoins involving a three-component reaction with the aid of deep eutectic solvent. Here, N,N'-dimethyl urea and N,N'-dimethyl thiourea play a dual role as reactant and reaction medium along with l-(+)-tartaric acid. The three-component reaction provides an easy access to 5-amino-1,3-dialkyl-substituted hydantoins and thiohydantoins in good yields.

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Citations

Apr 29, 2021·Organic & Biomolecular Chemistry·Mohammad Taghi NazeriBehrouz Notash

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