Multicomponent delirium prevention: not as effective as NICE suggest?

Age and Ageing
Elizabeth Teale, John Young

Abstract

Multicomponent delirium prevention strategies have been shown in intervention studies consistently to reduce the occurrence of delirium. Based on this convincing evidence base, the National Institute for Health and Care Excellence has advocated the widespread adoption of multicomponent delirium prevention interventions into the routine inpatient care of older people. However, despite successful reductions in incident delirium of about a third, anticipated reductions in mortality or admissions to long-term care--both clinically important endpoints statistically correlated with the occurrence of delirium--have not been conclusively observed. We hypothesise that the reasons for this disconnection are partly methodological, due to difficulties in delirium detection and blinding of study personnel to the intervention, but predominantly due to the underlying relationship between delirium and the abnormal health state of frailty; the interaction between these two geriatric syndromes is currently poorly understood.

References

Mar 4, 1999·The New England Journal of Medicine·S K InouyeL M Cooney
Apr 26, 2003·The American Journal of Medicine·Sidney T BogardusSharon K Inouye
Jan 19, 2007·Internal Medicine Journal·G A Caplan, E L Harper
Jul 4, 2007·Aging Clinical and Experimental Research·Maria LundströmYngve Gustafson
Jul 20, 2007·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Kenneth Rockwood, Arnold Mitnitski
Jul 29, 2010·JAMA : the Journal of the American Medical Association·Joost WitloxWillem A van Gool
Aug 19, 2010·JAMA : the Journal of the American Medical Association·Camilla L WongSharon E Straus
Mar 7, 2012·Age and Ageing·Eamonn M P EelesRuth E Hubbard

❮ Previous
Next ❯

Citations

Mar 15, 2016·International Psychogeriatrics·Luísa Lagarto, Joaquim Cerejeira
Mar 9, 2017·International Journal of Geriatric Psychiatry·Rowan H Harwood, Elizabeth Teale
Jul 25, 2019·Age and Ageing·Alasdair M J MacLullich, Susan D Shenkin
Jan 16, 2019·JAMA Network Open·Christopher W HalladayJames L Rudolph
Feb 6, 2020·Canadian Journal on Aging = La Revue Canadienne Du Vieillissement·Eamonn EelesAurelia Armstrong
Nov 1, 2017·Age and Ageing·Elizabeth Ann Teale
Apr 17, 2020·European Geriatric Medicine·Fabio SalviAntonio Cherubini
Jul 20, 2021·The Cochrane Database of Systematic Reviews·Jennifer K BurtonTerry J Quinn
Nov 27, 2021·The Cochrane Database of Systematic Reviews·Jennifer K BurtonTerry J Quinn

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.