Multicomponent nanocrystals with anti-Stokes luminescence as contrast agents for modern imaging techniques

Advances in Colloid and Interface Science
A N GeneralovaE V Khaydukov

Abstract

Lanthanide-doped upconversion nanoparticles (UCNPs) have recently attracted great attention in theranostics due to their exceptional optical and physicochemical properties, which enable the design of a novel UCNP-based nanoplatform for luminescent imaging, temperature mapping, sensing, and therapy. In addition, UCNPs are considered to be ideal building blocks for development of multimodal probes for cells and whole body imaging, exploiting simple variation of host matrix, dopant ions, and surface chemistry. Modalities responsible for magnetic resonance imaging (MRI), computed tomography (CT), and positron emission tomography (PET)/single-photon emission computed tomography (SPECT) are embedded in a single UC nanocrystal, providing integrating effect over any modality alone in terms of the efficiency and sensitivity for clinical innovative diagnosis through multimodal bioimaging. In particular, we demonstrate applications of UCNPs as a new nanoplatform for optical and multimodal cancer imaging in vitro and in vivo and extend discussions to delivery of UCNP-based therapeutic agents for photodynamic and photothermal cancer treatments.

Citations

Jul 31, 2018·Dalton Transactions : an International Journal of Inorganic Chemistry·Yana LiuHai-Bing Xu
Sep 17, 2019·Biochemistry. Biokhimii︠a︡·D A GvozdevV Z Pashchenko
Aug 12, 2020·Biomaterials Science·Polina A DeminaAlla N Generalova
Jul 10, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Polina DeminaEvgeny Khaydukov
May 28, 2020·Frontiers in Chemistry·Ivan V KrylovEvgeny V Khaydukov
Oct 30, 2020·Doklady. Biochemistry and Biophysics·R A AkasovV Ya Panchenko
Mar 6, 2021·Doklady. Biochemistry and Biophysics·P A DeminaS M Deev
May 14, 2021·Journal of Nanoscience and Nanotechnology·S FuentesJ León
Jun 24, 2021·Critical Reviews in Food Science and Nutrition·Deshmukh Abdul HakeemHongli Wen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Imaging

Imaging techniques, including CT and MR, have become essential to tumor detection, diagnosis, and monitoring. Here is the latest research on cancer imaging.