Multiday Transcranial Direct Current Stimulation Causes Clinically Insignificant Changes in Childhood Dystonia: A Pilot Study

Journal of Child Neurology
Nasir H BhanpuriTerence D Sanger

Abstract

Abnormal motor cortex activity is common in dystonia. Cathodal transcranial direct current stimulation may alter cortical activity by decreasing excitability while anodal stimulation may increase motor learning. Previous results showed that a single session of cathodal transcranial direct current stimulation can improve symptoms in childhood dystonia. Here we performed a 5-day, sham-controlled, double-blind, crossover study, where we measured tracking and muscle overflow in a myocontrol-based task. We applied cathodal and anodal transcranial direct current stimulation (2 mA, 9 minutes per day). For cathodal transcranial direct current stimulation (7 participants), 3 subjects showed improvements whereas 2 showed worsening in overflow or tracking error. The effect size was small (about 1% of maximum voluntary contraction) and not clinically meaningful. For anodal transcranial direct current stimulation (6 participants), none showed improvement, whereas 5 showed worsening. Thus, multiday cathodal transcranial direct current stimulation reduced symptoms in some children but not to a clinically meaningful extent, whereas anodal transcranial direct current stimulation worsened symptoms. Our results do not support transcranial direct ...Continue Reading

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Citations

May 14, 2016·Journal of Neural Transmission·Ulrich PalmFrank Padberg
Jul 4, 2016·Brain Stimulation·Marom BiksonAdam J Woods
Oct 25, 2016·Brain Sciences·Chao-Ying ChenBernadette T Gillick
Aug 8, 2017·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·R ErroK P Bhatia
Dec 21, 2016·Reviews in the Neurosciences·Guadalupe Nathzidy Rivera-UrbinaAndrés Molero-Chamizo
Mar 7, 2020·Journal of Neuroengineering and Rehabilitation·Helga HaberfehlnerAnnemieke I Buizer

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