Multidimensional analyses of long-term clinical courses of asthma and chronic obstructive pulmonary disease

Allergology International : Official Journal of the Japanese Society of Allergology
Toru OgaKoichi Nishimura

Abstract

Asthma and chronic obstructive pulmonary disease (COPD) are chronic respiratory disorders involving obstructive airway defects. There have been many discussions on their similarities and differences. Although airflow limitation expressed as forced expiratory volume in one second (FEV(1)) has been considered to be the main diagnostic assessment in both diseases, it does not reflect the functional impairment imparted to the patients by these diseases. Therefore, multidimensional approaches using multiple measurements in assessing disease control or severity have been recommended, and multiple endpoints in addition to FEV(1) have been set recently in clinical trials so as not to miss the overall effects. In particular, as improving symptoms and health status as well as pulmonary function are important goals in the management of asthma and COPD, some patient-reported measurements such as health-related quality of life or dyspnea should be included. Nonetheless, there have been few reviews on the long-term clinical course comparing asthma and COPD as predicted by measurements other than airflow limitation. Here, we therefore analyzed and compared longitudinal changes in both physiological measurements and patient-reported measuremen...Continue Reading

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Jun 4, 2020·Respiratory Research·Dave SinghMeiLan K Han
Apr 28, 2011·Current Opinion in Allergy and Clinical Immunology·Christopher Skappak, Erik J Saude
Mar 20, 2019·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Hyun Jung KooYeon Mok Oh
Dec 31, 2020·International Journal of Chronic Obstructive Pulmonary Disease·Wen-Chien ChengWu-Huei Hsu

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