Multidimensional Analysis of 16 Glucose Isomers by Ion Mobility Spectrometry

Analytical Chemistry
Maissa Mareme GayeNicola L B Pohl

Abstract

Diastereomeric adducts comprising an enantiomerically pure monosaccharide analyte, a peptide, and/or an amino acid and a divalent metal ion (for 16 different monosaccharide isomers) are generated by electrospray ionization and analyzed by combined ion mobility spectrometry-mass spectrometry (IMS-MS) techniques. Mobility distributions of [l-Ser + M + H](+) (where l-Ser is l-serine and M is a given monosaccharide), [l-Phe-Gly + M + H](+) (where l-Phe-Gly is l-phenylalanine-glycine), and [Mn(II) + (l-Phe-Gly - H) + M](+) complex ions are used to determine collision cross sections (ccs in Å(2)), and groups of cross sections for different clusters are proposed as means of identifying the sugar isomers. Within one type of complex, variations in ccs do not always allow delineation between the 16 glucose isomers, but interestingly, when ccs of three different ions are combined as a spatial vector, enantiomers are partially resolved. As a result of this analysis, l-glucose, d-glucose, l-allose, d-allose, d-gulose, d-galactose, and l-mannose are delineated, and for all eight enantiomeric pairs, d and l entities display different coordinates. In addition, different combinations of amino acids, peptide, and metal ions are surveyed, and the...Continue Reading

References

Jun 13, 1998·Analytical Chemistry·C S HoaglundD E Clemmer
May 8, 2001·Analytical Chemistry·W A TaoR G Cooks
Apr 10, 2002·Analytical and Bioanalytical Chemistry·D C Collins, M L Lee
Aug 15, 2002·Analytical Chemistry·W Andy TaoR Graham Cooks
Dec 21, 2002·Chemical Society Reviews·Lluïsa Pérez-García, David B Amabilino
Feb 15, 2005·Journal of Proteome Research·Stormy L KoenigerDavid E Clemmer
Jul 28, 2005·European Journal of Mass Spectrometry·Lianming Wu, R Graham Cooks
Apr 28, 2006·Protein Science : a Publication of the Protein Society·Rongjin GuanRoy A Mariuzza
Jun 15, 2006·Analytical Chemistry·Stormy L KoenigerDavid E Clemmer
Aug 17, 2006·Journal of the American Chemical Society·Sunnie MyungDavid E Clemmer
Jan 16, 2007·Analytical Chemistry·Samuel I MerenbloomDavid E Clemmer
Feb 23, 2008·Analytical Chemistry·Samuel I MerenbloomDavid E Clemmer
May 17, 2008·Analytical Chemistry·Timothy J Ward, Beth Ann Baker
Jul 26, 2008·Chirality·Maurizio SperanzaFabiana Subrizi
Sep 2, 2008·Journal of the American Society for Mass Spectrometry·Manolo D PlasenciaDavid E Clemmer
Oct 20, 2009·Journal of the American Society for Mass Spectrometry·Thierry Fouquet, Laurence Charles
Jan 7, 2011·Nature·Emilio J CocineroBenjamin G Davis
Feb 26, 2011·Angewandte Chemie·Ágnes RévészBohumil Dolenský
Sep 29, 2011·Journal of the American Society for Mass Spectrometry·Mohamed MajorLaurence Charles
Sep 29, 2011·Journal of the American Society for Mass Spectrometry·Brian C Bohrer, David E Clemmer
Jun 19, 2013·Mass Spectrometry Reviews·Hanan Awad, Anas El-Aneed
Jul 19, 2013·Journal of the American Society for Mass Spectrometry·Virginie DomalainCarlos Afonso
May 9, 2014·Journal of Mass Spectrometry : JMS·Virginie DomalainCarlos Afonso
Feb 6, 2015·Journal of the American Society for Mass Spectrometry·Gabe Nagy, Nicola L B Pohl

❮ Previous
Next ❯

Citations

Feb 17, 2018·Chirality·Xiaolei ChenSu Zeng
Mar 7, 2018·Journal of the American Society for Mass Spectrometry·David J HarveyWeston B Struwe
Aug 22, 2017·Analytical Methods : Advancing Methods and Applications·Gabe NagyNicola L B Pohl
Dec 7, 2018·European Journal of Mass Spectrometry·Virginie DomalainCarlos Afonso
May 18, 2019·Analytical and Bioanalytical Chemistry·Xueyun ZhengErin S Baker
Mar 30, 2019·Angewandte Chemie·Erik SaparbaevOleg V Boyarkin
Oct 19, 2017·Nature Communications·Baptiste SchindlerIsabelle Compagnon
Jan 26, 2021·Mass Spectrometry Reviews·Aurélie DelvauxSandra Alves
Feb 9, 2021·Critical Reviews in Food Science and Nutrition·Mahsa AlikordNabi Shariatifar
Mar 9, 2021·Analytical Biochemistry·Hiromori Murashima, Akimasa Fujihara
Nov 16, 2018·Journal of the American Society for Mass Spectrometry·Zachary WookeNicola L B Pohl
Jan 5, 2017·Journal of the American Society for Mass Spectrometry·Yanglan TanNicolas C Polfer
Jul 19, 2019·Journal of the American Society for Mass Spectrometry·Christopher S MallisDavid H Russell
May 10, 2017·Journal of the American Society for Mass Spectrometry·Vaibhav ShrivastavCarlos Larriba-Andaluz
Jun 24, 2017·Journal of the American Society for Mass Spectrometry·Chiara MasellisThomas R Rizzo
Oct 5, 2018·Journal of the American Society for Mass Spectrometry·Benjamin J BythellPhilippe Maître
Jun 25, 2021·Analytical Chemistry·Zhan GaoYuanjiang Pan
Jul 12, 2021·Biochimica Et Biophysica Acta. Proteins and Proteomics·Kirsty SkeeneCris Lapthorn
Aug 14, 2019·Journal of the American Chemical Society·Christopher J GraySabine L Flitsch
Jun 5, 2018·The Journal of Physical Chemistry. a·Daniele CanzaniMatthew F Bush
Jan 21, 2017·Analytical Chemistry·Stefan GaunitzMilos V Novotny

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.