Multidimensional associations between cognition and connectome organization in temporal lobe epilepsy.

NeuroImage
Raúl Rodríguez-CrucesLuis Concha

Abstract

Temporal lobe epilepsy (TLE) is known to affect large-scale structural networks and cognitive function in multiple domains. The study of complex relations between structural network organization and cognition requires comprehensive analytical methods and a shift towards multivariate techniques. Here, we sought to identify multidimensional associations between cognitive performance and structural network topology in TLE. We studied 34 drug-resistant adult TLE patients and 24 age- and sex-matched healthy controls. Participants underwent a comprehensive neurocognitive battery and multimodal MRI, allowing for large-scale connectomics, and morphological evaluation of subcortical and neocortical regions. Using canonical correlation analysis, we identified a multivariate mode that links cognitive performance to a brain structural network. Our approach was complemented by bootstrap-based hierarchical clustering to derive cognitive subtypes and associated patterns of macroscale connectome anomalies. Both methodologies provided converging evidence for a close coupling between cognitive impairments across multiple domains and large-scale structural network compromise. Cognitive classes presented with an increasing gradient of abnormalitie...Continue Reading

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Citations

Nov 26, 2020·Epilepsia·Sara LarivièreBoris C Bernhardt
Feb 10, 2021·Epilepsy Currents·Neda Bernasconi, Irene Wang
Mar 12, 2021·Epilepsia·Mauricio Girardi-SchappoNeda Bernasconi
May 26, 2021·Epilepsia Open·Bruce P HermannJana E Jones
May 28, 2021·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Christoffer Hatlestad-HallIra H Haraldsen
May 25, 2021·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Camille Garcia-RamosBruce Hermann
Aug 3, 2021·NeuroImage. Clinical·Ezequiel GleichgerrchtUNKNOWN ENIGMA-Epilepsy Working Group
Aug 28, 2021·Journal of the International Neuropsychological Society : JINS·William A SchraegleJeffrey B Titus
Sep 24, 2021·Nature Reviews. Neurology·Bruce P HermannCarrie R McDonald

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