Multidimensional Geriatric Prognostic Index, Based on a Geriatric Assessment, for Long-Term Survival in Older Adults in Korea

PloS One
Hee-Won JungKi Woong Kim

Abstract

The patient´s survival estimate is important for clinical decision-making, especially in frail patients with multimorbidities. We aimed to develop a multidimensional geriatric prognosis index (GPI) for 3- and 5-year mortality in community-dwelling elderly and to validate the GPI in a separate hospital-based population. The GPI was constructed using data for 988 participants in the Korean Longitudinal Study on Health and Aging (KLoSHA) and cross-validated with 1109 patients who underwent a geriatric assessment at the Seoul National University Bundang Hospital (SNUBH). The GPI, with a total possible score of 8, included age, gender, activities of daily living, instrumental activities of daily living, comorbidities, mood, cognitive function, and nutritional status. During the 5-year observation period, 179 KLoSHA participants (18.1%) and 340 SNUBH patients (30.7%) died. The c-indices for 3- and 5-year mortality were 0.78 and 0.80, respectively, in the KLoSHA group and 0.73 and 0.80, respectively, in the SNUBH group. Positive linear trends were observed for GPI scores and both 3- and 5-year mortality in both groups. In conclusions, using common components of a geriatric assessment, the GPI can stratify the risk of 3- and 5-year mor...Continue Reading

References

Jul 1, 1991·Journal of Geriatric Psychiatry and Neurology·W J BurkeS P Wengel
Jul 1, 1993·American Journal of Public Health·B M PosnerD R Miller
Mar 17, 2001·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·L P FriedUNKNOWN Cardiovascular Health Study Collaborative Research Group
Mar 20, 2004·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Linda P FriedGerard Anderson
Feb 16, 2006·JAMA : the Journal of the American Medical Association·Sei J LeeKenneth E Covinsky
Jan 12, 2012·JAMA : the Journal of the American Medical Association·Lindsey C YourmanAlexander K Smith
Sep 22, 2012·Journal of the American Geriatrics Society·UNKNOWN Guiding principles for the care of older adults with multimorbidity: an approach for clinicians
Feb 12, 2013·Lancet·Andrew CleggKenneth Rockwood
Aug 27, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Sahil MittalJames S Goodwin
Nov 20, 2013·Annals of Internal Medicine·Hyunsoon ChoAngela B Mariotto
Nov 30, 2013·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Jin Won KimJee Hyun Kim

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Citations

Jan 5, 2017·Journal of the American Medical Directors Association·Alberto PilottoFrancesco Panza
Mar 15, 2018·BMJ Case Reports·Maneka M BrittoJames C Lee
Mar 17, 2020·Ageing Research Reviews·Alberto PilottoLuigi Ferrucci

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Methods Mentioned

BETA
KLoSHA

Software Mentioned

STATA

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