Multidimensional imaging techniques for prediction of treatment response in major depressive disorder

Progress in Neuro-psychopharmacology & Biological Psychiatry
Scott A LangeneckerJonathan P Stange

Abstract

A large number of studies have attempted to use neuroimaging tools to aid in treatment prediction models for major depressive disorder (MDD). Most such studies have reported on only one dimension of function and prediction at a time. In this study, we used three different tasks across domains of function (emotion processing, reward anticipation, and cognitive control, plus resting state connectivity completed prior to start of medication to predict treatment response in 13-36 adults with MDD. For each experiment, adults with MDD were prescribed only label duloxetine (all experiments), whereas another subset were prescribed escitalopram. We used a KeyNet (both Task derived masks and Key intrinsic Network derived masks) approach to targeting brain systems in a specific match to tasks. The most robust predictors were (Dichter et al., 2010) positive response to anger and (Gong et al., 2011) negative response to fear within relevant anger and fear TaskNets and Salience and Emotion KeyNet (Langenecker et al., 2018) cognitive control (correct rejections) within Inhibition TaskNet (negative) and Cognitive Control KeyNet (positive). Resting state analyses were most robust for Cognitive control Network (positive) and Salience and Emotion...Continue Reading

Citations

Apr 16, 2019·Frontiers in Psychology·Scott A LangeneckerJon-Kar Zubieta
Dec 29, 2020·Progress in Neuro-psychopharmacology & Biological Psychiatry·Chien-Han Lai

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