Multidimensional scaling of diffuse gliomas: application to the 2016 World Health Organization classification system with prognostically relevant molecular subtype discovery

Acta Neuropathologica Communications
Patrick J CiminoEric C Holland

Abstract

Recent updating of the World Health Organization (WHO) classification of central nervous system (CNS) tumors in 2016 demonstrates the first organized effort to restructure brain tumor classification by incorporating histomorphologic features with recurrent molecular alterations. Revised CNS tumor diagnostic criteria also attempt to reduce interobserver variability of histological interpretation and provide more accurate stratification related to clinical outcome. As an example, diffuse gliomas (WHO grades II-IV) are now molecularly stratified based upon isocitrate dehydrogenase 1 or 2 (IDH) mutational status, with gliomas of WHO grades II and III being substratified according to 1p/19q codeletion status. For now, grading of diffuse gliomas is still dependent upon histological parameters. Independent of WHO classification criteria, multidimensional scaling analysis of molecular signatures for diffuse gliomas from The Cancer Genome Atlas (TCGA) has identified distinct molecular subgroups, and allows for their visualization in 2-dimensional (2D) space. Using the web-based platform Oncoscape as a tool, we applied multidimensional scaling-derived molecular groups to the 2D visualization of the 2016 WHO classification of diffuse glio...Continue Reading

References

Nov 15, 1988·Cancer·C Daumas-DuportP Kelly
Dec 1, 1996·Journal of Neurosurgery·M A MittlerE G Stopa
Feb 2, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J S SmithR B Jenkins
Mar 14, 2001·Journal of Neuropathology and Experimental Neurology·C GianniniH Altermatt
Jan 1, 1925·Proceedings of the National Academy of Sciences of the United States of America·P Bailey, H Cushing
Dec 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C Ryan MillerArie Perry
Jul 10, 2007·Acta Neuropathologica·David N LouisPaul Kleihues
Sep 6, 2008·Nature·UNKNOWN Cancer Genome Atlas Research Network
Feb 21, 2009·The New England Journal of Medicine·Hai YanDarell D Bigner
Feb 4, 2010·Acta Neuropathologica·Fonnet E BleekerCornelis J F Van Noorden
Apr 20, 2010·Cancer Cell·Houtan NoushmehrUNKNOWN Cancer Genome Atlas Research Network
Apr 1, 1940·Journal of Neurology and Psychiatry·H J Scherer
Aug 7, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Christian HartmannUNKNOWN German Glioma Network
Jul 6, 2014·Brain Pathology·David N LouisUNKNOWN International Society Of Neuropathology--Haarlem
Jun 11, 2015·The New England Journal of Medicine·UNKNOWN Cancer Genome Atlas Research NetworkJianan Zhang
Jun 11, 2015·The New England Journal of Medicine·Jeanette E Eckel-PassowRobert B Jenkins
Jul 27, 2015·Oncotarget·Heather E LeeperCaterina Giannini
Apr 28, 2016·Proceedings of the National Academy of Sciences of the United States of America·Hamid BolouriEric C Holland
Sep 23, 2016·The New England Journal of Medicine·Robert L GrossmanLouis M Staudt

❮ Previous
Next ❯

Citations

Mar 10, 2018·Advances in Anatomic Pathology·José E Velázquez Vega, Daniel J Brat
Aug 28, 2018·Current Opinion in Oncology·Marc BarritaultFrançois Ducray
Apr 30, 2019·Journal of Neuropathology and Experimental Neurology·Timothy E RichardsonKimmo J Hatanpaa
Apr 27, 2019·Der Pathologe·B Malzkorn, G Reifenberger
Jun 11, 2019·Acta Neuropathologica Communications·Kanish MirchiaTimothy E Richardson
Jul 11, 2020·Journal of Neuropathology and Experimental Neurology·Kristyn GalbraithTimothy E Richardson
Aug 14, 2020·Journal of Neuropathology and Experimental Neurology·Timothy E Richardson, Jamie M Walker
Dec 12, 2018·NPJ Precision Oncology·Malak AbedalthagafiKara M Foshay
Apr 9, 2019·Oncotarget·Patrick J Cimino, Eric C Holland
Sep 19, 2019·Journal of Neuropathology and Experimental Neurology·Rebecca A YodaPatrick J Cimino
Jul 23, 2020·Neuropathology and Applied Neurobiology·J K PetersenB W Kristensen
Jul 10, 2020·Neuro-oncology Advances·Mahmoud S AlghamriPedro R Lowenstein
Sep 22, 2020·Journal of Neuropathology and Experimental Neurology·Timothy E RichardsonJamie M Walker
Aug 31, 2018·Nature Genetics·Lisa G McFerrinEric C Holland
Jul 28, 2019·Acta Neuropathologica Communications·Kanish MirchiaTimothy E Richardson
May 29, 2020·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Cornelia BrendleBenjamin Bender
Feb 16, 2020·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Peter B DirksWilliam A Weiss
Sep 25, 2020·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Hans-Georg WirschingMichael Weller
Jan 26, 2021·Current Oncology Reports·Antonio DonoAnkush Bhatia
Nov 19, 2020·Neuro-oncology Advances·Matthew K BallCristiane M Ida
Feb 23, 2021·Neuro-oncology Advances·Nicholas NuechterleinPatrick J Cimino
Mar 28, 2021·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Jared T AhrendsenSanda Alexandrescu
Sep 11, 2021·Laboratory Investigation; a Journal of Technical Methods and Pathology·Takashi Komori
Sep 28, 2021·The Cancer Journal·Emile Pinarbasi, Drew Pratt

❮ Previous
Next ❯

Methods Mentioned

BETA
MDS
RNAseq

Software Mentioned

Genomic Commons
Markers and Patients
SPSS
GraphPad Prism
R package ‘ conumee
R Project for Computing
R
R Project for Statistical
Oncoscape

Related Concepts

Related Feeds

Cancer Incidence & Mortality

Cancer has emerged as a global concern due to its increase in incidence and mortality. Efforts are underway to evaluate and develop action plans to reduce the global burden of cancer. Currently, lung cancer, breast cancer and prostate cancer are the leading causes of cancer mortality. Here is the latest research on cancer incidence and mortality.