Multidirectional Efficacy of Biologically Active Nitro Compounds Included in Medicines

Pharmaceuticals
Dorota OlenderLucjusz Zaprutko

Abstract

The current concept in searching for new bioactive products, including mainly original active substances with potential application in pharmacy and medicine, is based on compounds with a previously determined structure, well-known properties, and biological activity profile. Nowadays, many commonly used drugs originated from natural sources. Moreover, some natural materials have become the source of leading structures for processing further chemical modifications. Many organic compounds with great therapeutic significance have the nitro group in their structure. Very often, nitro compounds are active substances in many well-known preparations belonging to different groups of medicines that are classified according to their pharmacological potencies. Moreover, the nitro group is part of the chemical structure of veterinary drugs. In this review, we describe many bioactive substances with the nitro group, divided into ten categories, including substances with exciting activity and that are currently undergoing clinical trials.

References

May 1, 1977·British Journal of Cancer·S DischeI R Flockhart
Aug 1, 1974·The British Journal of Radiology·J C AsquithJ A McFadzean
Jul 1, 1980·Canadian Anaesthetists' Society Journal·J R MaltbyR Phillips
Mar 1, 1982·International Journal of Radiation Oncology, Biology, Physics·M Guichard, E P Malaise
Feb 1, 1993·Antimicrobial Agents and Chemotherapy·D R AshtekarW Rittel
Feb 21, 2002·Trends in Endocrinology and Metabolism : TEM·Anders H BergPhilipp E Scherer
Feb 21, 2004·Science·Ronadip R BanerjeeMitchell A Lazar
Sep 2, 2004·Journal of Neural Transmission·A GordinH Teräväinen
Nov 17, 2004·Current Pharmaceutical Design·Clifton E BarryCynthia S Dowd
Feb 18, 2005·BJOG : an International Journal of Obstetrics and Gynaecology·Herman P van GeijnAnnemieke C Bolte
Nov 30, 2005·Biochemical Pharmacology·Kjetil AskPhilippe Camus
Dec 24, 2005·Expert Opinion on Investigational Drugs·Jeffrey W Clark
Jul 19, 2006·Current Medical Research and Opinion·K D Rainsford, UNKNOWN Members of the Consensus Report Group on Nimesulide
Aug 16, 2006·Journal of the American Academy of Dermatology·Akash A PatelCalvin O McCall
Jul 11, 2007·Journal of General Internal Medicine·Nina BuscemiManisha Witmans
Aug 9, 2007·Digestive Diseases and Sciences·Jari KoskenpatoMartti Färkkilä
Dec 7, 2007·Expert Review of Neurotherapeutics·Julie Leegwater-Kim, Cheryl Waters
Jan 5, 2008·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·L La MantiaC Milanese
Feb 21, 2008·The Journal of Biological Chemistry·Bruce A FreemanMarco d'Ischia
Apr 2, 2008·Current Infectious Disease Reports·Edsel Maurice T Salvana, Charles H King
Aug 13, 2008·Neurocritical Care·Susanne MuehlschlegelJohn R Sims
Nov 19, 2008·The Journal of Biological Chemistry·Volker RudolphBruce A Freeman
Jun 2, 2009·Current Microbiology·Iram LiaqatAnjum Nasim Sabri
Feb 18, 2010·Journal of the American Society of Hypertension : JASH·Brandi M WynneR Clinton Webb
Feb 23, 2010·Sleep Medicine Reviews·Monique A J MetsJoris C Verster
Dec 21, 2010·American Journal of Obstetrics and Gynecology·Jane R Schwebke, Renee A Desmond
Mar 12, 2011·Journal of Agricultural and Food Chemistry·Xiao Dong YanJian Ping Wang
Jun 21, 2011·The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·A H DiaconP R Donald
Sep 2, 2011·Future Medicinal Chemistry·Tathagata Mukherjee, Helena Boshoff
Nov 15, 2011·Current Pharmaceutical Design·Man Chin ChungJean Leandro dos Santos
Feb 18, 2012·Clinical and Vaccine Immunology : CVI·Javier A BustosUNKNOWN Cysticercosis Working Group in Peru
Dec 18, 2012·Science Translational Medicine·Genevieve C KendallM Carrie Miceli
Jan 22, 2013·Antimicrobial Agents and Chemotherapy·Christopher BotShane R Wilkinson
May 25, 2013·Chemistry Central Journal·Asmaa Ahmed El-Zaher, Marianne Alphonse Mahrouse
Sep 12, 2013·Redox Biology·Cassilda PereiraJoão Laranjinha
Sep 27, 2013·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·H Rubbo
Apr 22, 2014·Indian Journal of Dental Research : Official Publication of Indian Society for Dental Research·Jayam RavirajVenkata Suman

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Citations

Jul 26, 2018·Scientia pharmaceutica·Justyna Żwawiak, Lucjusz Zaprutko
Aug 28, 2019·Chemistry : a European Journal·Antonio BauzáTiddo Jonathan Mooibroek
Aug 21, 2020·Current Topics in Medicinal Chemistry·Martin KrátkýJarmila Vinšová
Feb 23, 2021·Journal of Pharmaceutical and Biomedical Analysis·Agnieszka PotęgaZofia Mazerska
Jul 15, 2020·Current Organic Synthesis·Manvinder KaurHarvinder Singh Sohal
Mar 14, 2019·ACS Synthetic Biology·Ran Zuo, Yousong Ding
Apr 16, 2020·ACS Medicinal Chemistry Letters·Mohmmad Younus WaniAbdullah Saad Al-Bogami

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Methods Mentioned

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