Multidisciplinary Interventions in Motor Neuron Disease

Journal of Neurodegenerative Diseases
U E WilliamsS K Oparah

Abstract

Motor neuron disease is a neurodegenerative disease characterized by loss of upper motor neuron in the motor cortex and lower motor neurons in the brain stem and spinal cord. Death occurs 2-4 years after the onset of the disease. A complex interplay of cellular processes such as mitochondrial dysfunction, oxidative stress, excitotoxicity, and impaired axonal transport are proposed pathogenetic processes underlying neuronal cell loss. Currently evidence exists for the use of riluzole as a disease modifying drug; multidisciplinary team care approach to patient management; noninvasive ventilation for respiratory management; botulinum toxin B for sialorrhoea treatment; palliative care throughout the course of the disease; and Modafinil use for fatigue treatment. Further research is needed in management of dysphagia, bronchial secretion, pseudobulbar affect, spasticity, cramps, insomnia, cognitive impairment, and communication in motor neuron disease.

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Citations

Nov 29, 2017·Cranio : the Journal of Craniomandibular Practice·Wen-Juh HwangJehn-Shyun Huang
Mar 30, 2021·International Journal of Speech-language Pathology·Rebecca FrancisSebastian Doeltgen
Jul 8, 2021·BMJ Case Reports·Brian GordonTimothy J Counihan

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