Multidomain intervention for the prevention of cognitive decline after stroke - a pooled patient-level data analysis

European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies
Yvonne TeuschlASPIS Study Group

Abstract

The aim of this pooled patient-level data analysis was to test if multidomain interventions, addressing several modifiable vascular risk factors simultaneously, are more effective than usual post-stroke care for the prevention of cognitive decline after stroke. This pooled patient-level data analysis included two randomized controlled trials using a multidomain approach to target vascular risk factors in stroke patients and cognition as primary outcome. Changes from baseline to 12 months in the trail making test (TMT)-A, TMT-B and 10-words test were analysed using stepwise backward linear mixed models with study as random factor. Two analyses were based on the intention-to-treat (ITT) principle using different imputation approaches and one was based on complete cases. Data from 322 patients (157 assigned to multidomain intervention and 165 to standard care) were analysed. Differences between randomization groups for TMT-A scores were found in one ITT model (P = 0.014) and approached significance in the second ITT model (P = 0.087) and for complete cases (P = 0.091). No significant intervention effects were found for any of the other cognitive variables. We found indications that multidomain interventions compared with standard ...Continue Reading

References

Oct 15, 2008·Dementia and Geriatric Cognitive Disorders·Marcin LeśniakAnna Członkowska
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Mar 31, 2017·International Journal of Stroke : Official Journal of the International Stroke Society·Yvonne TeuschlUNKNOWN ASPIS Study Group

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Citations

Mar 27, 2020·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Ragnhild Munthe-KaasIngvild Saltvedt
Oct 26, 2018·Stroke; a Journal of Cerebral Circulation·Michael Brainin, Yvonne Teuschl
Jul 6, 2020·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·S V KotovYu V Egorova
Aug 21, 2021·European Stroke Journal·Joanna M WardlawArne G Lindgren
Aug 29, 2019·Dementia and Geriatric Cognitive Disorders·Guri HagbergHege Ihle-Hansen

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