Multidrug efflux transporter ABCG2: expression and regulation.

Cellular and Molecular Life Sciences : CMLS
Samiksha KukalRitushree Kukreti

Abstract

The adenosine triphosphate (ATP)-binding cassette efflux transporter G2 (ABCG2) was originally discovered in a multidrug-resistant breast cancer cell line. Studies in the past have expanded the understanding of its role in physiology, disease pathology and drug resistance. With a widely distributed expression across different cell types, ABCG2 plays a central role in ATP-dependent efflux of a vast range of endogenous and exogenous molecules, thereby maintaining cellular homeostasis and providing tissue protection against xenobiotic insults. However, ABCG2 expression is subjected to alterations under various pathophysiological conditions such as inflammation, infection, tissue injury, disease pathology and in response to xenobiotics and endobiotics. These changes may interfere with the bioavailability of therapeutic substrate drugs conferring drug resistance and in certain cases worsen the pathophysiological state aggravating its severity. Considering the crucial role of ABCG2 in normal physiology, therapeutic interventions directly targeting the transporter function may produce serious side effects. Therefore, modulation of transporter regulation instead of inhibiting the transporter itself will allow subtle changes in ABCG2 ac...Continue Reading

References

Dec 23, 1998·Proceedings of the National Academy of Sciences of the United States of America·L A DoyleD D Ross
Apr 25, 2000·Biochemical and Biophysical Research Communications·E RocchiE Schneider
Feb 15, 2001·Oncogene·J S Yordy, R C Muise-Helmericks
Feb 28, 2002·Molecular Biology and Evolution·Kevin J Kolell, Douglas L Crawford
Jul 10, 2003·The Journal of Biological Chemistry·Masaki MogiKenneth Walsh
Sep 6, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Wandong ZhangDanica B Stanimirovic
Sep 25, 2003·The Journal of Biological Chemistry·Gregory A GrafHelen H Hobbs
Jan 30, 2004·International Journal of Cancer. Journal International Du Cancer·Shinji MizuaraiHidehito Kotani
Feb 20, 2004·Cancer Research·Robert W RobeySusan E Bates
Mar 18, 2004·International Journal of Cancer. Journal International Du Cancer·Laurent CandeilMaguy Del Rio
Mar 27, 2004·The Journal of Biological Chemistry·Partha KrishnamurthyJohn D Schuetz
Jun 24, 2004·Experimental Cell Research·Helen ClaytonMaria dM Vivanco
Sep 3, 2004·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J BartW T A van der Graaf
Sep 24, 2004·BMC Gastroenterology·Eric L KlettShailendra B Patel
Dec 8, 2004·Stem Cells·Annette P MeesonDaniel J Garry
Jan 11, 2005·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Dhanashri KolwankarTimothy S Tracy
Mar 4, 2005·Drug Metabolism and Disposition : the Biological Fate of Chemicals·R Robert VethanayagamQingcheng Mao
Apr 7, 2005·Neuroscience Research·Mohammed Omedul IslamJun Miyake
Apr 22, 2005·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Tappei TakadaYuichi Sugiyama
May 19, 2005·Leukemia Research·Marc H G P RaaijmakersReinier A P Raymakers
Jul 2, 2005·Cancer Letters·Patricia A FetschSusan E Bates
Aug 24, 2005·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Konrad MeissnerHeyo K Kroemer
Dec 13, 2005·Trends in Pharmacological Sciences·Antonius E van Herwaarden, Alfred H Schinkel
Dec 27, 2005·Pediatric Neurology·Alberto J LazarowskiAna Lía Taratuto
Dec 31, 2005·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Alexander AnapolskyMicheline Piquette-Miller
Jan 18, 2006·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Henriette E Meyer zu SchwabedissenHeyo K Kroemer
Mar 24, 2006·Biochemical and Biophysical Research Communications·Naren GuptaVadivel Ganapathy
Jul 1, 2006·The Journal of Pharmacology and Experimental Therapeutics·Frantisek StaudZdenek Fendrich

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Breast Cancer: Chemo-Resistance

Some cancers are difficult to treat and aggressive including the "triple-negative" breast cancer. This type of cancer is chemoresistant even before chemotherapy begins. Here are the latest discoveries chemo-resistance in breast cancer.

Related Papers

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences
Jian-Ting Zhang
International Journal of Biochemistry and Molecular Biology
Wei Mo, Jian-Ting Zhang
Journal of Experimental Therapeutics & Oncology
Toshihisa Ishikawa, Hiroshi Nakagawa
© 2021 Meta ULC. All rights reserved