Multidrug efflux transporters limit accumulation of inorganic, but not organic, mercury in sea urchin embryos.

Environmental Science & Technology
Ivana BosnjakAmro Hamdoun

Abstract

Mercuric compounds are persistent global pollutants that accumulate in marine organisms and in humans who consume them. While the chemical cycles and speciation of mercury in the oceans are relatively well described, the cellular mechanisms that govern which forms of mercury accumulate in cells and why they persist are less understood. In this study we examined the role of multidrug efflux transport in the differential accumulation of inorganic (HgCl(2)) and organic (CH(3)HgCl) mercury in sea urchin (Strongylocentrotus purpuratus) embryos. We found that inhibition of MRP/ABCC-type transporters increases intracellular accumulation of inorganic mercury but had no effect on accumulation of organic mercury. Similarly, pharmacological inhibition of metal conjugating enzymes by ligands GST/GSH significantly increases this antimitotic potency of inorganic mercury, but had no effect on the potency of organic mercury. Our results point to MRP-mediated elimination of inorganic mercury conjugates as a cellular basis for differences in the accumulation and potency of the two major forms of mercury found in marine environments.

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Citations

May 22, 2013·Environmental Science and Pollution Research International·Ivana BošnjakIvona Mladineo
Nov 6, 2012·The Journal of Biological Chemistry·Tufan GökirmakAmro Hamdoun
Mar 13, 2010·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Graham N GeorgeIngrid J Pickering
Feb 3, 2016·Journal of the Marine Biological Association of the United Kingdom·Matthew O GribbleCelia Y Chen
Apr 5, 2012·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Lauren E Shipp, Amro Hamdoun
Nov 21, 2013·Molecular Reproduction and Development·Jocelmo Cássio de Araujo LeiteLuis Fernando Marques-Santos
Aug 27, 2014·Molecular Reproduction and Development·Tufan GökirmakAmro Hamdoun
Jan 1, 2014·Environmental Toxicology and Chemistry·Anastasia GeorgantzopoulouAlbertinka J Murk
May 25, 2010·Environmental Pollution·Rui WangWen-Xiong Wang
May 27, 2014·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Till LuckenbachArmin Sturm
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Apr 8, 2016·American Journal of Physiology. Cell Physiology·Tufan GökirmakAmro Hamdoun
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Sep 24, 2015·Development·Lauren E ShippAmro Hamdoun
Mar 27, 2021·Metallomics : Integrated Biometal Science·Stephen A Pearson, J A Cowan

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