Multidrug resistance in breast cancer: from in vitro models to clinical studies.

International Journal of Breast Cancer
N S Wind, Ingunn Holen

Abstract

The development of multidrug resistance (MDR) and subsequent relapse on therapy is a widespread problem in breast cancer, but our understanding of the underlying molecular mechanisms is incomplete. Numerous studies have aimed to establish the role of drug transporter pumps in MDR and to link their expression to response to chemotherapy. The ATP-binding cassette (ABC) transporters are central to breast cancer MDR, and increases in ABC expression levels have been shown to correlate with decreases in response to various chemotherapy drugs and a reduction in overall survival. But as there is a large degree of redundancy between different ABC transporters, this correlation has not been seen in all studies. This paper provides an introduction to the key molecules associated with breast cancer MDR and summarises evidence of their potential roles reported from model systems and clinical studies. We provide possible explanations for why despite several decades of research, the precise role of ABC transporters in breast cancer MDR remains elusive.

References

Oct 7, 1992·Journal of the National Cancer Institute·R ClarkeR B Dickson
Sep 13, 1994·Proceedings of the National Academy of Sciences of the United States of America·G J ZamanH J Broxterman
Apr 1, 1996·The Journal of Experimental Medicine·M A GoodellR C Mulligan
May 20, 1999·Annual Review of Pharmacology and Toxicology·S V AmbudkarM M Gottesman
Jul 31, 1999·The Journal of Biological Chemistry·B D StrideR G Deeley
Mar 22, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Y Y LiuM C Cabot
May 11, 2001·Japanese Journal of Cancer Research : Gann·A KanzakiY Takebayashi
Jun 8, 2001·International Journal of Cancer. Journal International Du Cancer·I F FaneyteM J van de Vijver
Dec 26, 2001·Chemical Reviews·V Sharma, D Piwnica-Worms
Jun 5, 2002·Annual Review of Biochemistry·P Borst, R Oude Elferink
Aug 20, 2003·Molecular Biology of the Cell·Asha Rajagopal, Sanford M Simon
Feb 19, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Martin FilipitsRaimund Jakesz
Mar 16, 2005·The Breast : Official Journal of the European Society of Mastology·M VassilomanolakisA P Efremidis
Jan 6, 2006·Nature·John StinglConnie J Eaves
Apr 6, 2006·Pflügers Archiv : European journal of physiology·Piet BorstKoen van de Wetering
Jul 27, 2006·Pflügers Archiv : European journal of physiology·Gary D KruhZhe-Sheng Chen
Nov 10, 2006·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Yehuda G Assaraf
Feb 27, 2007·Cancer Metastasis Reviews·Robert W RobeySusan E Bates
Jul 13, 2007·Proceedings of the National Academy of Sciences of the United States of America·Sven RottenbergPiet Borst
Oct 31, 2008·Proceedings of the National Academy of Sciences of the United States of America·Sven RottenbergJos Jonkers
Feb 24, 2009·Nature Reviews. Molecular Cell Biology·Douglas C ReesOded Lewinson
Oct 3, 2009·Taiwanese Journal of Obstetrics & Gynecology·Fu-Shing Liu

❮ Previous
Next ❯

Citations

Oct 12, 2012·Cancer Chemotherapy and Pharmacology·Nicolay V LitviakovVladimir M Perelmuter
Aug 25, 2012·PPAR Research·Anthony J Apostoli, Christopher J B Nicol
Dec 31, 2014·Genetics Research International·Alessia CartaDuncan Ayers
Apr 1, 2012·Drug Delivery and Translational Research·Preethy PrasadXiao Yu Wu
Sep 26, 2013·European Journal of Cell Biology·Gabriela Nestal de MoraesRaquel C Maia
Nov 5, 2014·Journal of Enzyme Inhibition and Medicinal Chemistry·Ahmed MalkiAmal M Youssef
Dec 29, 2015·Biochimica Et Biophysica Acta·Vanessa Lopes-RodriguesM Helena Vasconcelos
Aug 27, 2014·International Journal of Cancer. Journal International Du Cancer·Yoonseok KamRobert A Gatenby
Jul 25, 2015·Molecular Carcinogenesis·Nadia PicotGilles A Robichaud
Aug 6, 2015·Nanomedicine·Vaibhav MundraRam I Mahato
Nov 12, 2013·European Journal of Medicinal Chemistry·Asmaa A SallamKhalid A El Sayed
Oct 21, 2014·Expert Opinion on Therapeutic Patents·Anna-Maria Katsori, Dimitra Hadjipavlou-Litina
Apr 20, 2016·Molecular Pharmaceutics·Marike W van GisbergenKatarina Johansson
Jul 18, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Nagendra S SinghIrving W Wainer
Oct 5, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Dan-Dan WangJin-Hai Tang
Sep 7, 2013·Journal of Extracellular Vesicles·Paulina Kucharzewska, Mattias Belting
Dec 26, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yunshan WangGuangwei Wei
Feb 24, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ahmed MalkiHayam Ashour
Jan 11, 2018·Journal of Cellular Physiology·Hadi NasiriJafar Majidi
Aug 3, 2018·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Padmanaban SivakumarMin Suk Shim
Jan 7, 2020·Current Drug Metabolism·Pooja Rathaur, Kaid Johar Sr
Jul 11, 2020·Cancers·Grace L WongHui-Wen Lo
Sep 2, 2016·Molecular Informatics·Natália AnicetoTaravat Ghafourian
Jun 6, 2018·Frontiers in Endocrinology·Angel Matias SanchezTommaso Simoncini
Sep 12, 2018·Cancer Cell International·Shao-Hsuan WenKuan-Rong Lee
Apr 25, 2018·Cancer Biomarkers : Section a of Disease Markers·Dora Molina-OrtizAraceli Vences-Mejía
Sep 12, 2018·Biochemistry. Biokhimii︠a︡·A A Stavrovskaya, E Yu Rybalkina
Nov 18, 2016·The American Journal of Chinese Medicine·Tito A SandovalSusana Fiorentino
Dec 13, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Marbelis Francisco FernandezBorhane Annabi
Dec 29, 2019·Scientific Reports·Mohammad AzharuddinHirak K Patra

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
xenograft
biopsy
imaging techniques

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
Katrien SwertsJan Philippé
FEBS Letters
Frederica L TheodoulouAlison Baker
Cancer Imaging : the Official Publication of the International Cancer Imaging Society
C Hegarty, C D Collins
© 2022 Meta ULC. All rights reserved