PMID: 8976731Nov 1, 1996Paper

Multidrug resistance in ocular melanoma

The British Journal of Ophthalmology
M McNamaraS M Kennedy

Abstract

Metastatic disease in patients with ocular melanoma is resistant to chemotherapy. One of the main mechanisms of modulating multidrug resistance is the expression of the multidrug resistance gene 1 (MDR1) product (p-glycoprotein) by tumour cells. The purpose of this study was to evaluate the frequency of expression of the MDR1 gene in ocular melanoma whose primary treatment was surgical excision or enucleation. Twelve recent ocular melanomas were received fresh, snap frozen and cryostat sections of tumour were analysed for expression of MDR1 by immunohistochemistry using a well characterised monoclonal antibody to MDR1. Tumour explants were established in short term tissue culture from four tumours and cell blocks were examined by immunohistochemistry. MDR1 expression was present in five of 12 ocular melanomas. Upregulation of protein expression was found in four cell lines established in short term culture from tumour explants. A recurrent tumour, initially treated by local excision and radioactive plaque, showed overexpression of MDR1 mRNA. These results suggest that significant level of MDR1 may be intrinsically present in ocular melanomas before exposure to drugs involved in multidrug resistance, and indicate the possible im...Continue Reading

References

Jan 1, 1977·Archives of Ophthalmology·M J McLeanL E Zimmerman
Jan 1, 1977·Archives of Ophthalmology·H F Shammas, F C Blodi
Jan 1, 1990·Human Pathology·R S WeinsteinJ S Coon
Oct 1, 1974·Cancer·L H EinhornJ A Gottlieb
Apr 1, 1981·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S M HsuH Fanger
Jul 15, 1983·Cancer·S RajpalC P Karakousis
May 1, 1981·Southern Medical Journal·A Y BedikianG P Bodey
Nov 23, 1995·The New England Journal of Medicine·N BaldiniM Campanacci
Jul 1, 1995·British Medical Bulletin·A C McCartney
Apr 1, 1995·The British Journal of Dermatology·D SchadendorfB M Czarnetzki
Jan 1, 1993·Journal of Cancer Research and Clinical Oncology·A RoessnerW Böcker
Sep 30, 1993·International Journal of Cancer. Journal International Du Cancer·A H SchinkelP Borst
Jun 1, 1993·The Journal of Surgical Research·E A LevineT K Das Gupta
Jan 1, 1996·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·L O'DriscollM Clynes

❮ Previous
Next ❯

Citations

Aug 4, 1992·Biochemical Pharmacology·C CuvierM F Poupon
Aug 17, 1996·Mutation Research·B J Sanderson, A J Shield
Mar 1, 1995·European Journal of Obstetrics, Gynecology, and Reproductive Biology·J KodamaT Kudo
Jan 1, 1990·Pharmacology & Therapeutics·A B Okey
Jan 19, 1996·Cancer Letters·M García-RochaJ Avila
Jan 1, 1996·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·G FountzilasD Skarlos
Feb 1, 1997·Leukemia Research·N RafkiJ Dufer
Mar 22, 2000·International Journal of Radiation Oncology, Biology, Physics·A FortinJ Landry
May 29, 2002·Surgical Oncology·D A Tolley, M P Esposito
Jun 10, 1998·Nuclear Medicine and Biology·V V RaoD Piwnica-Worms
May 5, 1999·Critical Reviews in Oncology/hematology·C E GiddingS S de Graaf
Sep 4, 2009·Pigment Cell & Melanoma Research·Kevin G ChenMichael M Gottesman
Feb 8, 2014·Journal français d'ophtalmologie·A PhiliponnetL G Baggetto
Dec 15, 2010·Journal français d'ophtalmologie·N Abi-AyadA Calender
Oct 19, 2007·The Journal of Investigative Dermatology·Marisa ColoneAgnese Molinari
Sep 1, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Sumita SethiJasbir Kaur
Jun 4, 2005·Clinical & Experimental Ophthalmology·João P Souza FilhoMiguel N Burnier
Nov 25, 2020·Bulletin of Experimental Biology and Medicine·S V SaakyanD D Garri
Sep 6, 2005·Journal français d'ophtalmologie·J GambrelleL G Baggetto

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Related Papers

Biochimica Et Biophysica Acta
G BradleyV Ling
Journal of Immunopharmacology
J A Teodorczyk-InjeyanL Makowka
International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
G P RaaphorstC E Ng
© 2022 Meta ULC. All rights reserved